Research On The Prediction Of Risk For Arteriogenic Erectile Dysfunction By Some Hematological Parameters

Purpose: Several hematological parameters have been shown to be strongly associated with cardiovascular disease,but few studies have evaluated their relationship with atherosclerotic erectile dysfunction(ED).The study was conducted to identify differences in hematological parameters between patients with arteriogenic erectile dysfunction(AED)and healthy controls through as comprehensive a hematological examination as possible and try to assess and predict AED with possible indicators.Methods: We randomly selected patients with ED from our urology or male outpatient clinics between November 2020 and May 2022,and all patients underwent a health questionnaire and basic physical examination(visual and palpation of the external genitalia,perineum,and groin area)to help exclude vascular,anatomical,neurological,hormonal,or other potentially influential factors.Eligible patients with AED and venous erectile dysfunction(VED)were then selected by nocturnal penile tumescence and rigidity(NPTR)and color duplex doppler ultrasound(CDDU).And sexually active,married,age-matched men were recruited from health centers as healthy controls.We collected relevant hematological parameters in detail for all subjects and compared the differences in the levels of these hematological parameters between the groups by appropriate statistical methods.Results: Finally,119 patients with AED and 64 patients with VED were included,and105 healthy men were recruited from health centers as controls.Statistically significant differences were found between AED and VED in terms of platelet-to-lymphocyte ratio(PLR),neutrophil-to-lymphocyte ratio(NLR),and mean platelet volume(MPV)(P<0.01).When comparing AED with the healthy group,we found statistically significant differences in the levels of white blood cells(WBC),NLR,PLR,MPV,triglycerides(TG),high-density lipoprotein cholesterol(HDL-C)and non-HDL-C(n-HDL-C)between the two groups.Receiver operating characteristic curve(ROC)analysis showed that NLR,PLR had the highest diagnostic value(NLR: area under the curve = 0.810,p < 0.001,best cut-off value = 1.995;PLR: area under the curve = 0.782,p < 0.001,cut-off value = 126.3).Conclusions: WBC,PLR,NLR,MPV,TG,HDL-C and n-HDL-C showed statistically significant differences between healthy individuals and patients with AED and can be considered as markers of AED,of which PLR and NLR were found to be the best diagnostic efficacy by ROC curve analysis.It suggests that hematological examination may be a convenient and effective method to help assess sexual function.Further detailed male examination should be actively given if there are high-risk signals on hematological indicators to reach early diagnosis and early treatment.