Study On The Role Of CA125 In Volume Evaluation Of Peritoneal Dialysis Patients

Background:With the increasing number of patients with chronic renal failure(ESRD),the number of dialysis patients is also increasing year by year.At present,more than 1/10 dialysis people(that is,more than 200000patients)are treated with peritoneal dialysis(PD).The mortality rate of dialysis patients is 8% higher than that of the general population,of which heart failure is the most common cause of death among dialysis patients.In patients with heart failure,the increase of BNP is not only associated with volume overload,but also with abnormal cardiac structure and function,while the increase of CA125 level is positively correlated with volume overload and atrial and pulmonary artery pressure.Therefore,the purpose of this study was to explore the role of serum CA125 in volume evaluation of peritoneal dialysis patients.Methods and results:The relationship between serum CA125,BNP and clinical volume markers and their prognostic value were studied in 90 patients with chronic renal failure who were treated in the outpatient and inpatient department of the Department of Nephrology of Qinhuangdao first Hospital.The higher the serum CA125 level,the more severe the degree of heart failure and the more symptoms and signs of volume overload.In multivariate regression analysis,higher levels of CA125 were associated with higher systolic blood pressure,more edema symptoms and volume overload.Conclusion:In peritoneal dialysis patients,the increase of BNP is related to abnormal cardiac structure and function,while serum CA125 is related to the symptoms,signs and calculated volume indexes of volume overload.Therefore,we believe that CA125 can be used as a marker of volume overload and assist BNP in the evaluation of volume status in peritoneal dialysis patients.