| Objective:Lung cancer is a malignant tumor originated from respiratory epithelial cells.The symptoms of lung cancer are diverse and unspectacular,which delays the diagnosis of lung cancer.The lung cancer diagnosed is often in the advanced stage,which leads to the mortality rate of lung cancer ranking first among all cancers.If lung cancer patients can be diagnosed as early as possible and receive effective treatment after diagnosis,the mortality rate of lung cancer will be reduced.Clinically,lung cancer patients commonly use low-dose computed tomography,tumor markers and other inspection methods to assist the diagnosis of lung cancer before receiving pathological biopsy.However,the shortcomings of LDCT are radiated,high technical cost and the risk of overdiagnosis,meanwhile the sensitivity and specificity of many tumor markers are not ideal.Therefore,this study attempts to explore an examination method for auxiliary diagnosis of lung cancer with low cost,high sensitivity and specificity,which is expected to provide more choices for clinic.MicroRNAs belong to non-coding RNA,which plays a regulatory role in the process of cell differentiation,development and apoptosis.The imbalance of microRNAs is closely related to the occurrence of tumors.MicroRNA-183 family(microRNA-183,microRNA-182,microRNA-96)can promote the proliferation and metastasis of lung cancer cells.At present,there have been many diagnostic experimental studies on microRNA-183 family,but the results of each study are quite different.In this study,the diagnostic value of microRNA-183 family in lung cancer is evaluated by meta-analysis,which is expected to explore a new method for clinical diagnosis of lung cancer.Methods:The Chinese and English medical databases were searched in turn,and the subject terms and free words of "lung cancer","microRNA-183","microRNA-182","microRNA-96","sensitivity","specificity",and "diagnosis" were searched in each database.The retrieval time was set from the establishment of each database to December 2022.After retrieving and screening the relevant literature and data,statistical data were calculated by using statistical software,and the heterogeneity among various diagnostic tests was evaluated.The source of heterogeneity was found by sensitivity analysis,meta-regression and subgroup analysis.Finally,the statistical data,the area under the curve and Fagan plot were combined to evaluate the diagnostic value of microRNA-183 family members in lung cancer.Results:Through searching and screening,11 diagnostic experimental studies are finally obtained,which includes 733 patients with lung cancer and 546 controls.These diagnostic tests have a sensitivity range of 41.1%-100.0%and a specificity range of 67.2%-87.2% for the diagnostic value of lung cancer.After meta-analysis,microRNA-183 family has a summary.The combined sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,odds ratio and the AUC of microRNA-183 family for lung cancer diagnosis were 0.81(95%CI:0.62-0.91),0.80(95%CI:0.76-0.83),3.96(95%CI:2.97-5.29),0.24(95%CI:0.11-0.52),16.31(95%CI:5.86-45.37)and 0.86 respectively.Conclusions:MicroRNA-183 family has certain diagnostic value for lung cancer,which can provide a supplement for clinical auxiliary diagnosis of lung cancer. |
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