Clinical Significance Of Combined Detection Of IL-6 And NLR In Osteoporosis In Patients With Chronic Obstructive Pulmonary Disease

Objective:To study the correlation between serum interleukin-6(IL-6),neutro phil-to-lymphocyte ratio(NLR)and osteoporosis(OP)in patients with chronic obstructive pulmonary disease(COPD).To explore the clinical significance of IL-6 combined with NLR detection in early prediction of osteoporosis in patients with chronic obstructive pulmonary disease.Methods:This study focuses on 80 COPD patients who met the inclusion criteria and were admitted to the Respiratory and Critical Care Medicine Department of Chengde Medical College Affiliated Hospital from November 2021 to February 2023.They were divided into COPD complicated with osteoporosis group(n=39)and COPD simple group(n=41)based on whether they were complicated with osteoporosis.The general information of the patients was analyzed,including age,gender,smoking index(SI)Body mass index(BMI),number of acute exacerbations in the past year,past history,systemic glucocorticoid use,and analysis of relevant clinical data,including white blood cell count(WBC),C-reactive protein(CRP),Calcitonin(PCT),calcium(Ca),phosphorus(P),25 hydroxyvitamin D Platelet to lymphocyte ratio(PLR),NLR,IL-6,oxygenation index(OI),lung function,etc.Apply SPSS 27.0 software to analyze the correlation between serum IL-6,NLR levels and COPD complicated with osteoporosis.The difference was statistically significant with P<0.05.Results:1.Comparison of general data between the two groups:There was no statistically significant difference in age,gender,BMI,SI,past history,number of acute exacerbations in the past year,and use of glucocorticoids between the two groups(P>0.05).2.Comparison of clinical data between the two groups:Compared with the simple COPD group,the serum CRP,NLR,WBC,and IL-6 levels in the COPD complicated osteoporosis group were significantly increased on average,with a statistically significant difference(P<0.05);Compared with the simple COPD group,the levels of serum Ca,25 hydroxyvitamin D,oxygenation index,forced expiratory volume in the first second/forced vital capacity(FEV1/FVC),and percentage of forced expiratory volume in 1 second to the predicted value(FEV1%pred)in the COPD osteoporosis group were significantly lower,There is a statistical difference(P<0.05);There was no statistically significant difference in serum PCT,PLR,platelet count(PLT),and P levels between the two groups(P>0.05).3.Logistic regression analysis:Single factor binary logistic regression analysis showed that WBC,NLR,and IL-6 were risk factors for COPD complicated with osteoporosis,while Ca,25 hydroxyvitamin D,OI,FEV1/FVC,and FEV1%pred were protective factors for COPD complicated with osteoporosis(P<0.05).Continuing to include the above variables in multivariate logistic regression analysis,the results showed that IL-6 and NLR were independent risk factors for COPD complicated with osteoporosis(P<0.05).4.The area under the ROC curve(AUC)value of IL-6 for predicting COPD complicated with osteoporosis is 0.881(95%CI:0.804～0.959),with a sensitivity of 0.897 and a specificity of 0.829.The area under the ROC curve(AUC)value of NLR for predicting COPD complicated with osteoporosis is 0.906(95%CI:0.839～0.973),with a sensitivity of 0.949 and a specificity of 0.805.The area under the ROC curve(AUC)value of the combined detection of the two for predicting COPD complicated with osteoporosis is 0.934(95%CI:0.877～0.990),with a sensitivity of 0.974 and a specificity of 0.780.5.Correlation analysis of IL-6,NLR and COPD complicated osteoporosis:Serum IL-6 levels are positively correlated with COPD complicated osteoporosis(r_s=0.661,P<0.001).The serum NLR level is positively correlated with COPD complicated with osteoporosis(r_s=0.703,P<0.001).Conclusions:1.High levels of serum IL-6 and NLR are independent predictive factors for COPD complicated with osteoporosis,and their combined detection has certain predictive value for the early detection of COPD complicated with osteoporosis;2.The levels of serum IL-6 and NLR are significantly correlated with COPD complicated with osteoporosis,indicating that they have a certain role in the occurrence and development of COPD complicated with osteoporosis.