TMS-EEG:Study Of Brain Function In Adolescents With Non-Suicidal Self-Injury

Research has shown that Non-suicidal self-injury(NSSI)exhibits a high degree of clinical heterogeneity,and adolescents with NSSI show abnormal electroencephalogram(EEG)compared to normal adolescents.Repetitive transcranial magnetic stimulation(r TMS)has been found effective in treating NSSI,but the impact of r TMS treatment on objective measures of therapeutic outcomes in NSSI adolescents remains unclear.This study aims to evaluate the effects of r TMS using synchronous transcranial magnetic stimulation-electroencephalogram(TMS-EEG)signals.Thirteen NSSI adolescents(aged13～25,with 11 females after quality control)were recruited.TMS-EEG data from the right dorsolateral prefrontal cortex were collected before and after r TMS treatment to explore the effects of r TMS on neurophysiological markers in NSSI adolescents,with the goal of providing reference for the clinical treatment of NSSI adolescents.1.The study focuses on the investigation of r TMS treatment on TMS-evoked potentials(TEP)amplitude and entropy changes in NSSI adolescents.Analyzing the intergroup differences in clinical assessment indicators,it was found that r TMS treatment can reduce the scores of clinical indicators such as non-suicidal self-injury,depression,and anxiety.Subsequently,TEP analysis and entropy analysis methods were used to study the effects of r TMS treatment on TEP amplitude and complexity in TMS-EEG signals of NSSI adolescents.The results showed that compared to before r TMS treatment,patients exhibited increased N45 amplitude in the left dorsolateral prefrontal cortex after treatment,while the approximate entropy and sample entropy in the right frontal lobe decreased.Furthermore,the decrease in sample entropy and approximate entropy showed a positive correlation with reduced self-rated anxiety scores.The results of this study indicate that r TMS treatment may have a positive effect on NSSI adolescents and can alter to some extent cortical inhibition,reducing the abnormal increase in complexity of TMS-EEG signals in NSSI patients,thereby establishing a more stable neural network.2.The study focuses on the investigation of r TMS treatment on cortical oscillations and functional brain network changes in NSSI adolescents.Through time-frequency domain analysis and functional brain network analysis methods,the changes in brain functional connectivity patterns in different frequency bands after r TMS treatment in NSSI adolescents were explored.The results showed that the connectivity of the brain functional network in NSSI adolescents was enhanced after r TMS treatment.Additionally,four network topological properties based on graph theory of TMS-EEG signals also changed after treatment,including decreased characteristic path length and increased clustering coefficient,global efficiency,and local efficiency.This indicates that r TMS treatment may can promote the recovery of randomized functional brain networks,enhance the ability of the brain to integrate and segregate information,and more efficiently construct brain networks.This study partially reveals the mechanism of r TMS treatment in NSSI adolescents and provides valuable insights for the diagnosis and treatment of NSSI adolescents.