| Cataract is a common blinding eye disease,and phacoemulsification cataract surgery is a safe and effective surgical procedure to treat cataracts.The number of patients with diabetes mellitus is increasing year by year,and the fundus complication diabetic retinopathy caused by long-term hyperglycemia is increasing accordingly.It has been demonstrated that the corneal endothelium in patients with diabetes is easy to damage and difficult to recover.The effect of non-proliferative diabetic retinopathy on corneal endothelial changes after phacoemulsification in diabetic patients was investigated in this study.Methods:A retrospective study.A total of 81 patients with type 2 diabetes,including 39 males and 42 females,underwent phacoemulsification combined with intraocular lens implantation by the same operator in Cangzhou People’s Hospital from October 2021 to June 2022.The patients were divided into two groups according to whether they had non-proliferative diabetic retinopathy.The observation group consisted of cataract patients with non-proliferative diabetic retinopathy(38 cases and 38eyes),and the control group consisted of cataract patients with diabetes mellitus without diabetic retinopathy(43 cases and 43 eyes).Corneal endothelial cell data were obtained before surgery,1 week after surgery,4weeks after surgery,and 12 weeks after surgery in both groups.Independent sample T-test was applied to analyze the change in corneal endothelial cell density(ECD),coefficient of variation(CV),and hexagonal cell ratio(HEX)between groups at each time,and ANOVA with repeated measures design was applied to compare the time effect,between-group effect,and interaction effect of changes in corneal endothelial cell density,coefficient of variation,and proportion of hexagonal cells in the two groups at different times.In all analyses,P <0.05 was considered a statistically significant difference.Results:1.The differences in ECD,CV,and HEX changes between the observation group and the control group at 1 week postoperatively,4 weeks postoperatively,and 12 weeks postoperatively were not statistically significant.2.There were significant differences in the time effects of ECD,CV,and HEX within the two groups,and there were no statistically significant differences in group effects and interaction effects.the changes in ECD and HEX decreased over time after surgery,and the changes in CV increased over time after surgery.Conclusions:1.A significant decrease in corneal endothelial cell density,an increase in corneal endothelial cell coefficient of variation and a decrease in the proportion of corneal endothelial hexagonal cells in diabetic patients after phacoemulsification cataract surgery.2.In diabetic patients,nonproliferative diabetic retinopathy had no significant effect on corneal endothelial cell density,coefficient of variation,or changes in the proportion of hexagonal cells after cataract ultrasound emulsification compared with patients who did not develop diabetic retinopathy. |
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