Clinical Observation Of Huatan Huoxue Sanjie Prescription In The Treatment Of Phlegm-stasis Internode Lung Nodules

Objective: Through the clinical observation of Huatan Huoxue Sanjie prescription in the treatment of lung nodules with the type of intermingled phlegm and blood stasis,this study observed the changes of the maximum diameter,number,TCM syndrome integral and the malignant risk integral and other related indicators of pulmonary nodules before and after treatment,thus objectively evaluating the clinical efficacy of this prescription in the treatment of lung nodules,and providing reference for further clinical and basic research on the treatment of lung nodules by traditional Chinese medicine.Methods: Patients with pulmonary nodules in this study were randomly divided into the treatment group that grants Huatan Huoxue sanjie prescription and the control group followed up with CT alone according to the corresponding inclusion and exclusion criteria established in advance.The course of TCM intervention in this study was 3months.After treatment,the maximum diameter and number of pulmonary nodules in the two groups before and after treatment were observed,recorded and compared.Changes in TCM syndrome integral and malignant risk integral before and after treatment were collected by scale,and the data were processed and analyzed.Results: The final number of cases included after shedding one patient from the control group was thirty in the treatment group and twenty-nine in the control group.Before treatment,there were no statistical differences in the general information and efficacy indicators between the two groups(P >0.05),indicating that the two groups were comparable.After statistical analysis,the results were as follows:(1)Maximum diameter of pulmonary nodules and clinical effect analysis: By comparing the preceding treatment with subsequent treatment,we found that the maximum diameter of the treatment group was lessened to some extent(P<0.05),but the change of the control group was not obvious(P>0.05),and there was a statistical difference between the two groups(P<0.05).The total efficiency rate of maximum diameter lessening in the treatment group was 26.70%,which was markedly higher6.90% than the control group,indicating that the treatment group was superior to the control group in lessening the maximum diameter of nodules.(2)Analysis of changes in the number of pulmonary nodules: There was no statistically significant change in the number of nodules between the two groups before and after treatment(P>0.05).(3)The analysis on TCM syndromes integral and clinical effect of pulmonary nodules:The TCM symptoms integral was significantly reduced in the treatment group(P<0.05),but had insignificant changes in the control group(P>0.05)before and after treatment.There were statistical differences between the two groups.The total efficiency rate of TCM syndromes effect in the treatment group was 70.00%,which was apparently higher 10.34% than the control group,showing that the treatment group was better than the control group in lowering the TCM syndromes integral and improving the clinical symptoms of patients.(4)The integral analysis on malignant risks of pulmonary nodules: There was no statistical significance of integral difference in Mayo Model between the two groups before and after treatment(P >0.05).The integrals of Brock Model and VA Model in the treatment group were decreased after treatment(P <0.05).But there were no significant changes in control group(P>0.05).The contrastive differences both had statistical significance in the two groups(P<0.05),which illustrated that the treatment group was superior to the control group in reducing the integrals between Brock Model and VA Model.Conclusion: Huatan Huoxue Sanjie formula can effectively reduce the size of lung nodules for the type of intermingled phlegm and blood stasis,so as to improve clinical symptoms of patients and reduce the risk of nodule degeneration,which has certain clinical application value and significance to further research.