Effects Of Gandou Decoction Combined With Dual Task Training On Balance Function In Patients With Dampness-Heat Intrinsic Type Of Encephalic Wilson Disease

Objective:To explore the effects of Gandou decoction combined with dual task training on balance function in patients with dampness-heat intrinsic type of encephalic Wilson disease,and to provide new basis and ideas for the understanding and treatment of balance disorders.Methods:1.Grouping: According to the inclusion criteria and exclusion criteria,90 patients with brain type WD damp-heat syndrome with balance dysfunction were randomly divided into three groups: A,B and C,with 30 people in each group.Among them,Group A is the Gandou Decoction combined with dual task training group(rhubarb 6g,coptis 12 g,scutellaria baicalensis 12 g,Lysimachia 12,Scutellaria barbata 12 g,Bixie 10g),Group B is the Gandou Decoction group,and Group C is the dual task training group.In combination with the criteria of exfoliation and exclusion,a total of 81 patients were finally collected as the final study object,and 27,26 and 28 patients were collected from the three groups respectively.2.Indicators and efficacy: The treatment lasted for 4 courses of 8 days each,including 1dose/day of Gandou decoction,divided into 2 doses of 200 ml/time;Dual task training30-40 min/time,1 time/day.Before and after treatment,they were assessed with the scale:(1)Berg Balance Scale scores(BBS).(2)Dual Task Up and Go Test Scale score(DTUG).(3)Ability to Perform Daily Living Scale score(Barthel Index,BI).(4)WD Rating Scale Scores(UWDRS).(5)Chinese Medicine Evidence Score Scale scores.Results:1.Comparison of basic data: Through statistical analysis,there was no difference in gender,age and course of disease among the three groups(P>0.05).2.Intra-group comparison: BBS score of patients in group A increased significantly after treatment compared with that before treatment(z=-4.549,P<0.01);The BBS score of patients in group B was higher than that before treatment(t=-2.722,P=0.012<0.05);There was no difference in BBS score of patients in group C before and after treatment(t=-2.014,P=0.54>0.05).Comparison between groups: After treatment,the BBS score of patients in group A was significantly higher than that of patients in group B and C(P<0.01);There was no difference in BBS score between group B and group C after treatment(P=0.894>0.05).3.Intra-group comparison: After treatment,the DTUG score of patients in Group A was significantly lower than that before treatment(t=13.664,P<0.01);The DTUG score of patients in group B was lower than that before treatment(t=2.419,P=0.023<0.05);There was no difference in DTUG score of patients in Group C before and after treatment(Z=-1.25,P=0.211>0.05).Comparison between groups: After treatment,the DTUG score of patients in group A was significantly lower than that of patients in group B and C(P<0.01);There was no difference in DTUG scores between group B and group C after treatment(P=0.202>0.05).4.Intra-group comparison: After treatment,the BI score of patients in Group A was significantly higher than that before treatment(Z=-4.481,P<0.01);The BI score of patients in group B was higher than that before treatment(Z=-2.306,P=0.021<0.05);There was no difference in BI scores of patients in group C before and after treatment(t=-1.052,P=0.302>0.05).Inter-group comparison: After treatment,the BI score of patients in Group A was significantly higher than that of patients in Group B and C(P<0.01);There was no difference in BI scores between group B and group C after treatment(P=0.605>0.05).5.Intra-group comparison: After treatment,the UWDRS scores of the three groups of patients decreased significantly(P<0.01).Comparison between groups: After treatment,the UWDRS score of patients in group A was significantly lower than that of patients in group B and C(P<0.01);There was no difference in UWDRS score between group B and group C after treatment(P=0.485>0.05).6.Intra-group comparison: After treatment,the TCM syndrome score of the three groups of patients decreased significantly compared with that before(P<0.01).Comparison between groups: After treatment,the TCM syndrome score of patients in Group A was significantly lower than that of patients in Group B(P=0.006<0.01)and patients in Group C(P<0.01);There was no difference in the score between group B and group C(P=0.413>0.05).Conclusion:(1)The study found that,on the basis of the treatment of copper expelling drugs,the use of Gandu decoction and Gandu decoction combined with dual task training has a certain effect on the improvement of balance disorder and overall symptoms in patients with brain type WD with damp-heat accumulation.(2)The study found that compared with the treatment effects of the three groups on the balance disorder of patients with brain type WD,the treatment effect of Gandou decoct ion combined with dual task training was significant,while the treatment effect of Gan dou decoction was general,while the treatment effect of simple dual task training was not good.(3)Gandou decoction has the characteristics of high curative effect,good safety and low cost.The double task training operation is simple and convenient,and the safety is high.Therefore,Gandou decoction combined with the double task training can be used as a new treatment for the balance disorder of patients with brain type WD,which is suitable for clinical promotion.