Clinical Study Of Yiqi Shuxue Decoction In The Treatment Of Stable Angina Pectoris Of The Qi Deficiency And Blood Stasis Type Of Coronary Heart Disease

Objective:The clinical efficacy and safety of Yiqi Shuxue Yin were evaluated by observing the clinical symptoms,blood lipid level,hs-CRP and SOD in patients with stable angina pectoris of coronary heart disease with qi deficiency and blood stasis,and providing a theoretical basis for clinical treatment.Methods:A total of 64 patients with stable angina pectoris of coronary heart disease in the Department of Cardiology of the first affiliated Hospital of Anhui University of traditional Chinese Medicine from September 2020 to September 2022 were selected,the syndrome differentiation of TCM was qi deficiency and blood stasis syndrome.There were 32 cases in the control group and 32 cases in the treatment group by using random number table.The control group was treated with secondary preventive drugs for coronary heart disease,and the treatment group was additionally treated with Yiqi Shuxue Yin for a total of 4 weeks.The TCM syndrome score,angina pectoris score,ECG changes,nitroglycerin stopping rate,blood lipid level,hs-CRP and SOD in the two groups were recorded respectively,and at the same time,the changes of routine safety indexes of subjects before and during treatment were monitored.The clinical efficacy of Yiqi Shuxue Decoction was comprehensively analyzed and its safety was evaluated.Result:1.General materialsBoth control group and treatment group shed 2 cases for some reason,and a total of 60 cases were completed.Before treatment,there was no significant difference between the two groups(P > 0.05),which were comparable.2.Efficacy indicators(1)TCM syndrome score and curative effect: After treatment,on the one hand,TCM syndrome scores of two groups are decreased,and the improvement effect of the treatment group was better obviously(P<0.05).On the other hand,the effective rate of the control group(73.33%)was inferior than the treatment group(83.33%),and the curative effect of the treatment group was better.(2)Comparison of angina pectoris score and curative effect: Angina scores in both groups were lower than before,but the decline was more obvious in the treatment group(P<0.05).At the same time,the effective rate of the treatment group(90.00%)was higher than that of the control group(73.33%),with statistical significance(P<0.05).(3)Comparison of the efficacy of electrocardiogram: The results showed that the ECG of the two groups showed an improvement trend,73.33% and 83.33% respectively.However,after data analysis,there is no obvious difference.(4)Comparison of stop reduction rate of nitroglycerin: The amount of nitroglycerin used in the two groups decreased after treatment,and the degree of reduction of the treatment group was more significant(P<0.05).(5)Laboratory examination: The blood lipid indexes of the two groups had a relatively obvious downward trend in terms of TG,TC,and LDL-C,particularly in the treatment group(P<0.05).There was no significant change in HDL-C level(P>0.05);In terms of hs-CRP and SOD,both groups were improved compared with the former,and the improvement trend in the treatment group was obvious(P<0.05).3.Safety evaluation: Before and after the study,subjects in both groups did not have three major routine abnormalities,liver and kidney function damage,etc.And no adverse reactions was occurred.The safety of Yiqi Shuxue Decoction is worthy of recognition.Conclusion:Yiqi Shuxue Decoction can further improve the TCM syndromes and clinical symptoms of stable angina pectoris of coronary heart disease with Qi deficiency and blood stasis on the top of basic therapy,improve the levels of blood lipids,hs-CRP and SOD,and decrease the use of nitroglycerin.With good safety,which is worthy of clinical application and promotion.