| Purpose:The patients with Cancer-related insomnia(CRI)were treated with heat-sensitive moxibustion.The subjective and objective sleep quality and serum indexes were monitored before and after treatment,and to understand the effect of heat-sensitive moxibustion on relieving the symptoms of traditional Chinese medicine and improving the quality of life of CRI patients with heart-kidney disharmony.Method:To recruit 2021 CRI patients with heart-kidney discordance admitted to the department of Oncology,First Affiliated Hospital of the People’s Anhui University of Traditional Chinese Medicine of China between October and October 2022 as volunteers,60 patients with heat-sensitive acupoints were randomly divided into control group and test group with 30 patients in each group.On the basis of maintaining the original treatment plan of the Department of Oncology,the control group was treated with oral estazolam tablet before sleep,while the experimental group was treated with heat-sensitive moxibustion.Both groups were treated continuously for 14 days.SRSS,Karnofsky(KPS)and TCM symptom score were recorded before treatment,after treatment and during follow-up.The levels of serum IL-2,IL-6 and TNF-α were measured before and after treatment in both groups.SPSS23.0 was used for data analysis.Result:General information: there was no significant difference between the two groups in sex,age,disease type and tumor stage.Clinical efficacy:Total score of SRSS: the total score of the two groups after treatment was lower than that before treatment(P & LT;0.05),the score of the control group after treatment was lower than that of the treatment group(P & LT;0.05),the results showed that both treatments could improve the TCM syndrome,but the improvement of sleep in estazolam group was better than that in the heat-sensitive moxibustion group,and the total score of the control group increased after follow-up,the total score of the treatment group was still lower than that of the control group(P & Lt;0.05),but the total score of the treatment group was still lower than that of the control group(P & Lt;0.05),and the total score of the treatment group was still lower than that of the control group(P ≪0.05),the difference was statistically significant,indicating that after treatment,heat-sensitive moxibustion had a certain therapeutic effect on insomnia of tumor patients,and the long-term therapeutic effect was better than that of the estazolam group.The total scores of TCM symptoms in both groups after treatment were lower than those before treatment(P & LT;0.05),and the scores of treatment group after treatment were lower than those of control group(P & Lt;0.05),the results showed that both treatments could improve the TCM symptoms of the patients,but the improvement of the TCM symptoms by heat-sensitive moxibustion was better than that by estazolam moxibustion,and the total scores of both groups were recovered after follow-up,but the total scores of the treatment group were still lower than those before treatment(P & LT;0.05),the total score of the treatment group was still lower than that of the control group(P & Lt;0.05),and the difference was statistically significant,indicating that the effect of heat-sensitive moxibustion on Heart-kidney disharmony syndrome was still maintained after the treatment,better than estazolam.5.The single score of TCM symptom scale: the scores of insomnia,upset and palpitation in the two groups after treatment were lower than those before treatment(p < 0.05),the difference was statistically significant,in the treatment group,the scores of sweating,soreness and weakness of waist and knee,mental fatigue and forgetfulness after treatment were lower than those before treatment.There was a significant difference between the scores before and after treatment(p < 0.05).The results showed that heat-sensitive MOXIBUSTION was superior to estazolam in improving the symptoms of heart-kidney disharmony.In the treatment group,the scores of TCM symptom scales were significantly higher than those before treatment(p < 0.05),which indicated that heatsensitive moxibustion could maintain the improvement of the related symptoms of heart-kidney disharmony,it is better than estazolam in maintaining the curative effect.Single Item Score of TCM symptom scale: the scores of insomnia,upset and palpitation in both groups after treatment were lower than those before treatment,p <0.05,the difference was statistically significant.After treatment,the scores of the treatment group were lower than those before treatment in such aspects as sweating,soreness of waist and knee,mental fatigue and forgetfulness.The scores before and after treatment were statistically significant(p < 0.05).The results showed that heatsensitive moxibustion was superior to estazolam in improving the symptoms of heartkidney disharmony In the treatment group,there were significant differences in the scores of TCM symptom scales between before and after treatment(p < 0.05),it can be seen that heat-sensitive moxibustion has a certain maintenance effect on the improvement of heart-kidney disharmony-related symptoms,and is superior to estazolam tablets in maintaining the efficacy.After treatment,the total length of sleep and deep sleep increased significantly in both groups(P & LT;0.05),the results showed that both estazolam and moxibustion could improve the quality of insomnia,and the duration and times of arousal in both groups were significantly lower than those before treatment(P & LT;0.05),the results showed that both heat-sensitive moxibustion and estazolam treatment could increase the wakefulness threshold,and the number of sleep cycle rotation in the treatment group was significantly lower than that before treatment(P & LT;0.05),it is indicated that heat-sensitive moxibustion can reduce the alternation of sleep time items,improve the stability of insomnia and increase the efficiency of insomnia.The serum levels of IL-2,IL-6 and TNF-α in the treatment group were not significantly different from those in the control group before and after treatment(P > 0.05),there was no significant difference in the levels of IL-2,IL-6 and TNF-α between the two groups after treatment(P > 0.05).Considering that cytokines are influenced by many factors,such as tumor type,tumor stage,routine treatment in hospital,and patients’ basic health status,the controllability is poor,moreover,the mechanism of intervention of IL-2,IL-6 and TNF-α on sleep is not clear enough,so there is no obvious change of IL-2,IL-6 and TNF-α in this study. |
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