Effect Of Mild Hypothermia Combined With Namefene On Hypertensive Intracerebral Hemorrhage In Different Age Groups

Objective:Through research and analysis of the data of hypertensive intracerebral hemorrhage patients admitted to the affiliated hospital of Youjiang Medical College for Nationalities from January 2018 to December 2022,the effect of mild hypothermia combined with nalmefene treatment for ICH patients of different age groups was discussed,so as to provide theoretical basis for more individualized and refined diagnosis and treatment of patients of different ages.Methods:By collecting and selecting the detailed clinical data of 280 patients with hypertensive cerebral hemorrhage admitted in January 2018-The Affiliated Hospital of Youjiang Medical College for Nationalities from December 2022,three groups were divided into WHO age groups(young group18-44,middle-aged group 45-59 and older group 60-70).According to the inclusion criteria,the efficacy of the patients was analyzed from different aspects(intracranial pressure,cerebrospinal fluid lactate content,cerebrospinal fluid glucose content,GCS and CT).Results:(1)Intracranial pressure: The intracranial pressure in each group gradually decreased(p<0.05),and on the first day of treatment,there was no significant difference between the young group and theolder group(p>0.05),while the intracranial pressure in the middle-aged group was lower than that in the young group and the older group(p<0.05).On day 4 and day 7 of treatment,there was no statistical difference in intracranial pressure in the young and middle-aged groups(p>0.05),which was lower than that in the older group,with a significant difference(p<0.05).(2)Cerebrospinal fluid glucose: The glucose content of cerebrospinal fluid decreased gradually in each group(p<0.05).On the day 1 and day 4 days of treatment,there was no difference between the young group and the middle-aged group(p>0.05),and both were higher than the old group,and the difference was statistically significant(p<0.05).On the seventh day of treatment,there was no difference in CSF glucose between the young group and the middle age group(p>0.05),but the CSF glucose content was gradually lower than that in the old group,which was statistically significant(p<0.05).(3)Cerebrospinal fluid lactic acid: The lactic acid content in each group decreased gradually(p<0.05).On the first day of treatment,there was no significant difference between the young group and the middle age group(p>0.05),while the younger group and the content were higher than the older group(p<0.05);there was no difference between the middle age group and the older group(p>0.05).On day 4 and 7 days of treatment,there was no difference in cerebrospinal fluid lactic acid between youth group and middle age group(p>0.05),and both were lower than the older group,which was statistically significant(p<0.05).(4)GCS score:The GCS score gradually increased in each group(p<0.05).On the first day of treatment,the score of the youth group was slightly higher than that of the elderly group(p<0.05),while there was no significant difference between the middle-aged group and the youth group(p>0.05).There was no significant difference between the middle-aged group and the older group(p>0.05).On day 4 and day 7 of treatment,the scores of the young and middle-aged group were gradually higher than the old group,with significant differences(p<0.05),while there was no significant difference between the young and middle-aged groups(p>0.05).(5)Midline recovery rate: In the comparison of the 1 to 4 days after treatment,there was no difference between the young and middle age groups(p>0.05),while the recovery rate of both groups was higher than that of the older group,with a significant difference(p<0.05).In the comparison of the recovery rate from 4 to 7 days after treatment,there was no statistical difference in the recovery rate between the young group and the older group(p>0.05),and the recovery rate of the middle age group was higher than that of the young group and the older group(p<0.05).Conclusion:(1)In this study,mild hypothermia combined with nalmefene is effective in the treatment of hypertensive cerebral hemorrhage at different ages.(2)There was little difference in the efficacy of mild hypothermia combined with nalmefene in hypertensive cerebral hemorrhage patients in the young and middle-aged groups.(3)The efficacy of subhypothermia combined with nalmefene treatment was better in patients with hypertensive cerebral hemorrhage in the young and middle-aged groups than that in the older group.