Analysis Of Related Influencing Factors Of M1 Segment Occlusion Of Middle Cerebral Artery In Western Guangxi Zhuang Autonomous Region

Objective: The objective of this study was to investigate the factors associated with middle cerebral artery(MCA)M1 occlusion in the population of western Guangxi,aiming to provide a theoretical foundation for identifying high-risk factors and preventing cerebrovascular diseases.Methods: The study included patients from the Department of Neurology at our institution(Affiliated Hospital of Youjiang Medical College for Nationalities)who underwent cerebral angiography between February 1,2019,and September 1,2022.DSA procedures were performed by an experienced director of cerebral angiography.The results revealed that the observation group consisted of patients with M1 segment occlusion,while the control group comprised patients without any abnormalities.Target subjects were selected based on predetermined inclusion and exclusion criteria,resulting in 45 patients in the observation group and 48 age-matched patients in the control group.Basic information and relevant laboratory parameters were recorded for all enrolled patients.The collected data were statistically analyzed using SPSS 26.0 software,employing univariate and multivariate non-Logistic regression analyses.Results:(1)Univariate analysis revealed statistically significant differences between the two groups in terms of diabetes history,coronary heart disease history,hypertension history,triglycerides,homocysteine,cholesterol,high-density lipoprotein,creatinine,uric acid,cystatin-c,and direct bilirubin(all P < 0.05).Additionally,the mean values of high-density lipoprotein indexes were higher in the control group,while other indexes were higher in the observation group compared to the control group.(2)Univariate analysis demonstrated no statistically significant differences in sex,ethnicity,ALT,AST,low-density lipoprotein,albumin,and indirect bilirubin between the two groups(P > 0.05).(3)Multivariate unconditional logistic regression analysis indicated that high-density lipoprotein and a history of coronary heart disease showed significant differences(P < 0.05)in their association with M1 segment occlusion.Conclusion:(1)Coronary heart disease,diabetes,hypertension,triglyceride,cholesterol,homocysteine,creatinine,uric acid,cystatin C and direct bilirubin are the risk factors for M1 segment occlusion of middle cerebral artery in the west of Guangxi,while high-density lipoprotein is a protective factor.(2)High-density lipoprotein and coronary heart disease are relatively independent risk factors for M1 segment occlusion of middle cerebral artery in the population of western Guangxi.