The Half Maximal Effective Concentration Of Remimazolam In Pediatric Anesthesia Induction Was Explored Based On The Probit Mode

Objective : To explore the semi-maximum effect concentration of Remimazolam in pediatric general anesthesia induction based on the probit model,and to observe the safety and efficacy of Remimazolam in pediatric anesthesia induction,and to provide a theoretical basis for Remimazolam in pediatric general anesthesia induction。Methods:According to the inclusion and exclusion criteria set in this study,55 children with routine surgery for endotracheal intubation and general anesthesia from April 2021 to August 2021 were selected,aged2-14 years,with ASA grades of I.-II.Part I: The first 15 participants were randomly divided into three groups of A,B and C,each group of 5 people,given Remimazolam 0.3,0.4,0.5 mg/kg,respectively,by observing the success rate of sedation to determine the starting dose of the second part of the experiment sequential method.The second part: 40 samples were included,the initial dose was designed according to the sequential method of 0.4mg/kg(the first part of the experiment was obtained),the concentration gradient was 0.025mg/kg,when the sedation effect was satisfactory,the next study subject lowered a concentration gradient,and vice versa,it increased a concentration gradient,and when the "unsatisfactory-satisfactory" intersection appeared 6 times,the experiment was stopped,using the probit model probabilistic unit regression analysis method.The ideal EC50 and corresponding 95%confidence interval(95% CI)for the induction measurement of Remimazolam for pediatric anesthesia induction were calculated.The basal heart rate,blood pressure,and oxygen saturation of the subject when he entered the operating room(T0)and completed the tracheal intubation(T2)were recorded,the patient status index(PSI)of the subject was < 50 hours(T1)(t),and the number of adverse events such as injection pain,choking cough,nausea and vomiting,and allergies during the entire induction process were recorded and the treatment measuresResults:Using probabilistic unit regression analysis of the probit model,the EC50 of Remimazolam for the ideal dose induced by pediatric general anesthesia was calculated to be 0.483 mg/kg,its 95% CI was0.474 mg/kg – 0.495 mg/kg,and the drug onset time was 66.03±2.906 seconds.There was no significant change in heart rate at T0 and T2(P>0.05);systolic blood pressure at to and from TO2(P>0.05);diastolic blood pressure at to and T2(P<0.05);and MAP at to and T2(P<0.05).During the induction process,2 cases of sinus bradycardia were found to have adverse reactions,and no other adverse reactions were seen.Conclusion: Remimazolam can be safely used in the induction of general anesthesia in pediatric patients,with a semi-effective concentration of 0.483 mg/kg in a single induction dose,0.474 mg/kg –0.495 mg/kg in 95% CI,and an average onset time of 66.03±2.906 seconds.In the induction process,it almost did not cause changes in the heart rate and systolic blood pressure of pediatric patients,and had a certain effect on diastolic blood pressure and average arterial pressure,which was manifested as a slight decrease,but the degree of decline did not exceed 20% of the basal blood pressure,and no serious adverse events were seen in the whole study process...