Clinical Outcomes And Prognostic Analysis Of 101 Patients Of Central Neurocytoma

Background and objective: Central neurocytoma(CN)is a rare type of tumor that currently lacks an optimal treatment protocol.This study aimed to explore the clinical outcomes of CN in a cohort of 101 patients and identify prognostic factors associated with multiple treatment modalities.Methods: This monocentric study retrospectively analyzed the clinical data of 101 CN patients who underwent surgical resection and were pathologically confirmed in our hospital from April 2010 to September 2020.The patients were followed up,and their overall survival(OS)and progression-free survival(PFS)were calculated to analyze the clinical features,treatment strategies,clinical outcomes and factors affecting the prognosis of central neurocytoma.Results: For the entire cohort,the 5-and 10-year OS rates were88.7% and 82.8%,respectively,and the 5-and 10-year PFS rates were86.5% and 64.9%,respectively.Of the 82(81.19%)patients with CN who underwent gross total resection(GTR),28(28/82,34.1%)also received radiotherapy(RT).Of the 19(18.81%)patients with CN who underwent subtotal resection(STR),11(11/19,57.9%)also received RT or stereotactic radiosurgery(SRS).Compared to STR,GTR significantly improved the 5-year OS(92.4% vs.72.4%,P=0.011)and PFS(92.4% vs.60.4%,P=0.009)rates.Radiotherapy did not affect OS in the GTR group(p=0.602),but it had a statistically significant effect on OS in the STR group(p < 0.001).However,the OS(P=0.842)and PFS(P=0.915)in the STR plus radiotherapy group were comparable to those in the GTR alone group.Compared to STR alone,STR plus radiotherapy improved the5-year PFS rate from 25% to 75% in patients with atypical CN(P=0.004).Cox regression models and a competing risk model showed that the removal degree and radiotherapy were independent prognostic factors for survival.Severe radiotherapy toxicity was not observed.Conclusion: Central neurocytoma is a rare type of intracranial tumors that occur in the lateral ventricles and have an overall good prognosis.The first choice of treatment for these tumors remains surgical resection.The prognosis is better with total surgical resection than with subtotal surgical resection.Our findings support the use of GTR whenever possible and safe.Radiotherapy can improve the OS and PFS of patients who undergo STR.