| Introduction: Patients with Temporal Lobe Epilepsy(TLE)often exhibit attention impairment,but the pattern and the mechanism of attention impairment are still unclear.Eye tracking technology,which can effectively capture visual information closely related to eye movement,combined with cognitive task state can objectively represent eye movement representation.Objective: The purpose of this study was to use eye tracking technology combined with attention task state to characterize the characteristic impairment pattern of attention function in TLE patients.Methods: Thirty-seven TLE patients and 29 healthy controls(HCs)were recruited to complete Attention Network Test(ANT)using an automated computer-based assessment platform with eye tracker.Visit time,fixation time,first fixation time,saccade time of area of interests(AOIs)and saccade path were recorded and analyzed.Results: The TLE patients had significantly lower orienting network score than that of the HCs in the ANT scale(t=-2.400,p=0.019)and eye tracking analysis(t=-2.114,p=0.039).And there is a positive correlation of orienting network score between ANT scale and eye tracking analysis(r=0.58,p<0.05).Furthermore,the mean first saccade time to the region of interest 2(Region of Interest,ROI2)time was significantly positively correlated with the mean response time in the ANT scale(r(66)=0.70)under the condition of spatial cue.Conclusion: TLE patients may have a characteristic pattern of attention impairment,in which significant impairment of orientation function presented,in combination of defects in processing speed and accuracy,and manifested in an eye movement pattern with increased saccades and wider range of saccade.The application of computer-based eye tracking technology combined with ANT task state can objectively portray the characteristic eye movement patterns of attention impairment,which provides us a deep understanding of the underlying neural mechanism of TLE-related cognitive impairment. |
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