Analysis Of Prognostic Factors Of Intrahepatic Cholangiocarcinoma

Purpose:Intrahepatic cholangiocarcinoma(HCC)is the second most malignant tumor of liver.Due to its high degree of malignancy and poor differentiation,most patients have entered the middle and late stage at the time of diagnosis,and the prognosis is poor.In this paper,through retrospective analysis of clinical cases,the postoperative risk factors were discussed in order to provide new ideas for the prevention and treatment of intrahepatic cholangiocarcinoma.Method:A total of 39 cases of intrahepatic bile duct cell carcinoma confirmed by postoperative pathology after radical hepatectomy were analyzed retrospectively in the Department of Hepatobiliary and Pancreatic Surgery of the Second Hospital of Jida from July 2014 to October 2022.The clinical data included in the study mainly include: Overall survival time,history of hepatitis and biliary tract surgery,ECOG score,preoperative and postoperative liver function,tumor markers,CT,MRI and other imaging examinations,surgical method,scope of lymph node dissection,pathological type,degree of differentiation,mode of invasion,TNM stage,intraoperative hilar occlusion time,postoperative complications,postoperative TACE,postoperative radiotherapy and chemotherapy,etc.All clinical data were processed by statistical software,and the results were compared and analyzed.Results:After univariate analysis(Kaplan-Meier method,Log-rank method),the factors with statistical significance(P < 0.05)included: ECOG score(P = 0.000),intraoperative hilar occlusion time(P = 0.000),postoperative adjuvant therapy(P = 0.010),lymph node metastasis(P = 0.001),tumor size(P = 0.003),degree of differentiation(P = 0.006),and hepatic capsule invasion(P = 0.016).In order to eliminate the interference factors among the above variables,the Cox regression model in the survival analysis module was further used to screen out the independent factors related to ICC postoperative prognosis.After multivariate analysis,the factors with statistical significance(P < 0.05)were ECOG score(P = 0.032),intraoperative hilar occlusion time(P = 0.018),tumor size(P = 0.032),lymph node metastasis(P = 0.035)and differentiation degree(P = 0.021).Conclusion:ECOG score,intraoperative hilar occlusion time,tumor size,lymph node metastasis,and degree of differentiation were independent factors influencing survival and prognosis of ICC patients.