Clinical And Electroencephalographic Features,Treatment And Prognosis Of Focal Seizures In Adults

Object:To summarize and analyze the clinical and EEG characteristics,etiology,imaging,treatment and prognosis of adults FS,and further explore the relevant factors affecting seizure recurrence and to help clinicians and patients to better control seizures.Methods:A statistical analysis was performed on 150 patients admitted to the hospital with FS and perfected EEG between January 2018 and July 2022.They were then collected their clinical data,including age,sex,prior neurological history,etiology,clinical presentation,EEG,imaging,and oral antiepileptic drugs.Results:Of the 150 Patients,91(60.67%)were male,59(39.33%)were female,average age(56.73±14.17),and 50? 70 years(59.33%)were predominant.Acute etiology of seizure was higher in 77 cases(51.3%).Cerebrovascular disease accounted for the highest percentage of etiologies in 58 cases(38.67%),followed by encephalitis in 30cases(20%).The main seizure type was focal motor seizure,manifesting as unilateral limb clonus was the most common.A total of 142 people had perfected imaging examinations,and 106 cases(74.65%)had lesions involving the cortex.There were51 cases with background abnormalities on EEG,and 64 cases(42.67%)of epileptic discharges were monitored during the interictal period(located in the frontal,temporal,parietal,occipital,central,and anterior head regions,respectively,with the temporal region accounting for the largest proportion);38 cases(25.33%)of seizures were monitored,with the following origins: 8 cases in the frontal region,7 cases in the temporal region,1 case in the occipital region,6 cases in the frontotemporal region,3 cases in the occipitotemporal region,2 cases in the central frontal region,1case in the central parietal region 1 case,frontoparietal-occipital region 1 case,clinical presentation was focal,EEG showed unknown origin in 5 cases.111 of 150patients used antiepileptic drugs after seizure,and oxcarbazepine and levetiracetam surpassed carbamazepine as the clinician’s first choice for focal seizures in 94 patients who used antiepileptic drugs after seizure.At≥6 months follow-up,47 were lost,6patients died,41 patients(39.81%)still had seizures and 56 patients(54.37%)had no seizures.There were no significant difference in age,sex,prior neurohistory,involvement of cortical lessions,and background rhythm abnormalities,Seizures monitored by EEG between recurrent and no-recurrent groups.Seizures without acute etiology and interictal epileptic discharges on EEG suggested a higher risk of short-term recurrence.Take anti-epileptic medication immediately after a seizures reduce the risk of a short-term relapse.Conclusion:The most common causes of focal seizures in adult inpatients are cerebrovascul ar disease and encephalitis,and the most common form of seizure is focal motor s eizure.2.Interictal EEG epileptiform discharges suggest a high risk of recurrence wit hin 6 months.3.In adult inpatients with seizures with acute disease 6 months s eizure risk is lower and antiepileptic drug application is individualized.