| Objective:By comparing the efficacy of taking different doses of dimethicone emulsion on the intestinal tract of patients,a more appropriate dose of dimethicone emulsion was explored to ensure the efficacy of effacing while minimizing the residue of dimethicone emulsion in the colonoscopy tube and reducing the difficulty of colonoscopy cleaning.Methods:Using a randomized controlled approach,170 patients who met the inclusion and exclusion criteria for performing colonoscopy were selected as study subjects from August to November 2022 at a tertiary care endoscopy center in Changchun,Jilin Province.The study subjects were divided into groups A(control group),B(trial 1 group)and C(trial 2 group)using a computer-generated random number table and according to the different doses of dimethicone emulsion.The intestinal cleansing regimen of polyethylene glycol solution was the same for all three groups,But when taking the remaining 200 m L of polyethylene glycol solution 4-6 hours before the examination on the same day,20 m L,10 m L,and 5 m L of dimethicone emulsion were added to the three groups,respectively,and then mixed and taken.The dose of dimethicone emulsion was determined by comparing the efficacy of bowel blister removal,cleansing,bowel preparation tolerance and post-examination tolerance,cecum intubation rate,time to enter,time to exit,saline injection volume and lesion detection during colonoscopy and the ease of oil scrubbing of the colonoscopy clamp tube used by the three groups of patients.IBM SPSS Statistics 26.0 statistical software was used to analyze the data,and descriptive statistics,X~2test,one-way ANOVA,Kruskal-Wallis test,Mann-Whitney U test and other statistical analysis methods were used to analyze the data,P<0.05 was considered as a statistically significant difference significance,and two-by-two comparison between groups,adjusting the significance cut-off value,with P<0.05/3=0.017 as a statistically significant difference.Results:170 patients were finally included in this study.There were 57 cases in group A,58 cases in group B,and 55 cases in group C.The differences in general information as well as underlying medical history and examination indications among the three groups were not statistically significant(P>0.05)and were comparable.There was no statistically significant difference in the comparison of intestinal cleansing effect among the three groups(P>0.05);the difference in the comparison of intestinal expectoration effect among the three groups was statistically significant(P<0.05),among which there was no statistically significant difference between group A and B(P>0.017),no statistically significant difference between group B and C(P>0.017),and statistically significant difference between group A and C(P<0.017).The intestinal expectoration score of diabetic patients in the three groups was lower and the difference between the groups was not statistically significant(P>0.05).There was no statistically significant difference(P>0.05)in the comparison of intestinal preparation tolerance in all three groups;the difference in the occurrence of postoperative bloating in the three groups was statistically significant(P<0.05),with a statistically significant difference(P<0.017)in the comparison of groups A and C,no statistically significant difference(P>0.017)in the comparison of groups A and B,and no statistically significant difference(P>0.017)in the comparison of groups B and C.statistically significant(P>0.017).The cecum intubation rate was 100%in all three groups,and there was no statistically significant difference(P>0.05)in the comparison between the three groups in terms of the time to enter,the time to exit and the amount of saline injection as well as the diagnostic results of colonoscopy and the detection of polyps/adenomas.When the three groups of colonoscopy clamp tubes were cleaned,five of them in group A had a cleaning difficulty of grade 1 and two had a cleaning difficulty of grade2;two of them in group B had a cleaning difficulty of grade 1;and all of them in group C had a cleaning difficulty of grade 0.The difference between the three groups was statistically significant(P<0.05).the difference between the two groups of AB was not statistically significant(P>0.017),the difference between the two groups of BC was not statistically significant(P>0.017),and the difference between the two groups of AC was statistically significant(P<0.017).Conclusion:The administration of 10 m L of dimethicone emulsion before colonoscopy can ensure the efficacy of blister removal,reduce the risk of oil residue in colonoscopy,and reduce the difficulty of colonoscopy cleaning.However,the dose of dimethicone emulsion for intestinal blister removal in diabetic patients still needs to be further explored and studied. |
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