Value Of Fibrinogen To Albumin Ratio In Predicting In-hospital Major Adverse Cardiovascular Events In STEMI Patients After PCI

Purpose:Acute ST-segment elevation myocardial infarction(STEMI)is one of the most critical types of coronary heart disease.It is characterized by short treatment time window,low quality of life,and high mortality.Despite the maturity of direct percutaneous coronary intervention and the timely treatment of patients,the probability of major adverse cardiovascular events during hospitalization is still high,which seriously affects the life quality of patients.This study sought to be a predictor of adverse events during hospitalization after PCI in STEMI patients,in order to provide reference for future clinical work to evaluate the prognosis of patients.Method:A total of 710 patients diagnosed with STEMI and whose clinical data were complete were included in this retrospective study from January 2021 to December2021 in the Department of Cardiovascular Medicine,the First Hospital of Jilin University.According to whether or not MACE occurred during hospitalization,188 cases were divided into MACE group and 522 cases were divided into without MACE group.The differences and similarities between the two groups were compared from basic data,laboratory test indicators,coronary artery severity,examination results and other aspects.Results:In terms of clinical data,there were no significant differences between the two groups in gender,smoking history,hypertension history,diabetes history and the number of diseased vessels(P> 0.05).In the comparison of age,LVEF value and Gensini score,there were significant differences between the two groups(P < 0.05).In the laboratory test data on the comparison of two groups of patients in the PLT,UA,TC,LDL,HDL-C-C and propagated,there was no significant difference(P > 0.05).There were significant differences in BNP,WBC,NE,Hb,BUN,SCr,AST,ALT,troponin peak,FIB and FAR between the two groups(P< 0.05).By Logistic regression analysis,found in patients with STEMI PCI after hospitalization,Gensini score,BNP,ALT,troponin peak and FAR was associated with a MACE occurred(P < 0.0.5).The results of ROC curve analysis showed that the area under the curve of FAR in the diagnosis of in-hospital MACE in STEMI patients after PCI was 0.747(95%CI0.704-0.790,P < 0.001),the diagnostic critical value was 0.087,the corresponding sensitivity was 66.5%,and the specificity was 73.6%.Conclusion:1.In terms of clinical data,patients in the MACE group were older,had worse cardiac function at admission,and had higher coronary Gensini scores than those in the non-MACE group.2.In terms of laboratory data,BNP,WBC,NE,BUN,SCr,AST,ALT,troponin peak,FIB and FAR of patients in the MACE group were higher than those in the non-MACE group,and Hb level was lower than that in the non-MACE group.3.The results of multivariate analysis showed that Gensini score,BNP,ALT,troponin peak and FAR were the predictors of MACE during hospitalization in STEMI patients after PCI.4.High FAR was an independent risk factor for MACE during hospitalization after PCI in STEMI patients.The diagnostic cut-off value of FAR for MACE in STEMI patients during hospitalization after PCI was 0.087.The higher the FAR value,the greater the probability of MACE was considered.