A Study On The Association Of Serum S100β Protein And C-reactive Protein In Cognitive Dysfunction

Objective:Exploring the relationship between serum levels of S100β protein,C-reactive protein,and cognitive impairment.Methods:This study selected patients from the First Affiliated Hospital of Nanchang University,including 52 cases of cognitive impairment(36 cases of Alzheimer’s disease,16 cases of mild cognitive impairment)and 16 cases of healthy controls(HC group).All participants underwent neuropsychological testing and serum S100β and CRP detection.The serum concentrations of S100β protein and CRP were dissimilarly compared between different groups,and the correlation between serum S100β protein and CRP levels and daily living activity assessment scores and MMSE scores was analyzed using correlation analysis.The diagnostic value of serum S100βprotein and CRP in Alzheimer’s disease was predicted using ROC curves,and the diagnostic accuracy was compared using the area under the curve(AUC).Results:(1)The MCI and AD groups had a significantly lower ability to perform daily living as well as nutritional status compared to the HC group(p < 0.001).(2)MMSE scores in the AD group were significantly lower than those in the HC group(p < 0.001)and MCI group(p <0.001).Serum S100β protein levels in the AD group were higher than those in the HC group(p = 0.001).There was no statistical difference in serum CRP levels between the three groups(p < 0.05).(3)Spearman correlation analysis showed a negative correlation between serum S100β protein levels and MMSE scores(r=-0.327,p<0.05).(4)S100β protein,CRP,education,age,albumin,creatinine,BI index,and homocysteine were included in a multifactorial linear regression analysis,which revealed an effect of serum S100β protein level(p = 0.041),education(p = 0.026),and age(p = 0.008)on cognitive function.(5)ROC curve analysis was performed,and the results showed AUC=0.756(95% CI 0.637-0.875)for S100β protein level.Conclusions:Serum S100β protein level is negatively correlated with cognitive function,while serum CRP level is not related to cognitive function evaluation.Serum S100βlevels can be used as biomarkers to aid in the diagnosis of Alzheimer’s disease.