Functional Connectivity Of The Primary Visual Cortex In Patients With Comitant Exotropia

Objective:This study is based on the resting state functional connection（RSFC）method,that is,the resting state functional magnetic resonance imaging（rs-fMRI）method and the seed point correlation analysis based functional connection（FC）method were used to study the difference of spontaneous functional connectivity of primary visual cortex（V1）between patients with concomitant exotropia（CE）and healthy controls（HC）.To explore the changes of spontaneous activity of primary visual cortex in patients with concomitant exotropia.Methods:In this study,From August 2021 to March 2022,24 patients with concomitant exotropia and 24 healthy controls（HC）in Jiangxi people’s Hospital were selected（sex and age matched with CE group）.Both groups were scanned by resting fMRI.The functional connections of the primary visual cortex of the two groups were analyzed by RSFC method,and the differences of functional connections of V1 between the two groups were compared by double sample t test.Results:Compared with the healthy control group,there was no significant difference in sex,age and best corrected visual acuity between the two groups.Compared with the HC group,the functional connection between the right V1 and the left V1 and Cerebelum₇b_L was enhanced in the CE group（GRF correction,voxel level P<0.001,cluster level P<0.001）.Conclusion:The enhancement of functional connection between bilateral V1 and the Cerebelum₇b_L in patients with CE may suggest that the cerebellum of CE patients has a compensatory increase in neural activity to compensate for the abnormality of binocular visual function,which provides a certain reference for the neuropathological mechanism of binocular visual function impairment in CE patients.