Clinical Efficacy Of Glucocorticoids In The Early Treatment Of Severe Acute Pancreatitis With Organ Damage

Objective:The efficacy of glucocorticoids in the treatment of severe acute pancreatitis and complicated organ damage was evaluated by relevant prognostic indicators,complication rates and infection conditions such as serological indicators（such as CRP,Ca2+concentration）and clinical events.Methods:A total of 94 patients with severe acute pancreatitis in the intensive care unit of the Second Affiliated Hospital of Nanchang University from January 2019 to February 2023 were collected,and the two groups of patients were divided into hormone group（treatment group,n=35 cases）and conventional group（control group,n=59 cases）according to whether glucocorticoids were used,and the patients in the conventional group were treated according to the conventional treatment and etiology of SAP,and methylprednisolone was added to the hormone group on the basis of conventional group treatment.Then,the data of the two groups of patients were collected,and the SPSS26.0 statistical software was used to analyze the baseline data,CRP,serum calcium and other clinical indicators,related clinical events,complications and infections before and after treatment,so as to evaluate the clinical efficacy of glucocorticoids on SAP and concurrent organ damage.Results:1.There was no significant difference in the baseline data of admission between the two groups of SAP patients.2.On the 3rd and 5th days after conventional treatment and conventional+hormone therapy,the CRP of the hormone group decreased compared with the pre-treatment in the two groups of SAP patients,and the difference was statistically significant（p<0.05）,while the difference in the conventional group was only statistically significant on the 5th day after treatment（p<0.05）.Ca2+increased in both groups on the 3rd and 5th days after treatment,and the difference was statistically significant（p<0.05）.At the same time,when comparing the values of CRP and Ca2+on the 3rd and 5th days after treatment between the hormone group and the conventional group,there was no significant difference（p>0.05）.3.There were no significant differences in the number of cases of CRRT,duration of mechanical ventilation,utilization rate of vasoactive drugs,length of ICU stay,total length of stay and mortality between the two groups in clinical events（p>0.05）.4.There were no significant differences in organ damage,electrolyte imbalance,gastrointestinal bleeding and hyperglycemia between the two groups of SAP patients in the event of complications（p>0.05）;5.There were no significant differences between the two groups of SAP patients in the site of emerging infection:lungs,abdominal cavity,urinary tract,blood and biliary tract（p>0.05）.Conclusion:Early glucocorticoids can act on SAP to improve CRP and Ca²⁺,Although there is no clear difference in improving organ damage,it does not increase the risk of infection.