Correlation Analysis Between Lower Muscle Strength And Nutritional In Patients With Chronic Airway Inflammatory Diseases

Objective:To investigate the changes of muscle strength and endurance of both lower limbs and nutritional status in patients with chronic obstructive pulmonary disease,and to further explore its correlation with lung function and C-reactive protein.Method:From August 2021 to June 2022,37 patients(23 males and 14females)with the age range of 39-77 years and the mean age of 59.22±8.92 years,were diagnosed with chronic obstructive pulmonary disease from the First Hospital of Jilin University.Meanwhile,20 healthy individuals(10 males and 10 females)were selected from the family members of the patients as the control group with the age range of 40-75 years and the mean age of 56.10±9.33 years.The differences in muscle strength and endurance of both lower limbs and nutritional status between the two groups were compared,as well as their correlation with lung function and CRP.The test indicators include: 1)the lung function indicators measured by the lung function tester,including forced vital capacity(FVC/pred%),forced expiratory volume in one second(FEV1/pred%),and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC);2)C-reactive protein(CRP)was measured by automatic biochemical analyzer;3)Height and weight were measured by a heightweight meter;4)Body composition was measured by body composition analyzer.The measured body composition included fat mass(FM),fat mass index(FMI),fat free mass(FFM),fat free mass index(FFMI),skeletal muscle mass(SMM),left leg SMM,right leg SMM,total body water(TBW)Extracellular water(ECW),total extracellular fluid / body fluid(ECW/TBW);5)The PT of flexion and extension at 60°/s and the total work of flexion and extension at 90°/s were measured by isokinetic muscle strength test.SPSS 25.0 data software was used for data analysis.Results:1.The skeletal muscle mass of the lower limbs of the patients in the experimental group was significantly lower than that of the healthy subjects in the control group,and the difference was statistically significant(P<0.05).2.Muscle strength and endurance of extension and flexion of the lower limbs of the patients in the experimental group were lower than those of the healthy subjects in the control group,and the difference was statistically significant(P<0.05).3.There was no significant relationship between CRP and nutritional composition,muscle strength and endurance of both lower limbs extension and flexion in patients with COPD(P > 0.05).4.There was a positive correlation between FM,FMI and FEV1/ pred%in COPD patients,and the difference was statistically significant(P < 0.05).FMI of COPD patients was positively correlated with FVC/pred%,and the difference was statistically significant(P < 0.05).BMI of COPD patients was positively correlated with FEV1/FVC after medication,and the difference was statistically significant(P < 0.05).5.Muscle strength and endurance of bilateral flexion in patients with COPD were positively correlated with FEV1/FVC after medication,and the difference was statistically significant(P < 0.05).Conclusions:1.Patients with COPD have decreased muscle mass in both lower limbs,suggesting that patients with COPD have abnormal nutritional status..2.Muscle strength and endurance of both lower limbs are significantly decreased in patients with COPD,suggesting that patients with COPD have decreased skeletal muscle function.3.The increase of fat weight(FM)and fat mass index(FMI)in COPD patients will increase FEV1 / pred(%),the increase of fat mass index(FMI)will increase FVC / pred(%),and the increase of body mass index(BMI)will increase FEV1 / FVC.It is presumed that the increase of fat in COPD patients may have a protective effect on patients.