A Meta-Analysis Of The Efficacy Of Omega-3 Polyunsaturated Fatty Acids In Patients Undergoing Chemotherapy

Objective: Chemotherapy is an important means in tumor therapy,which can make cancer cells die or stop growing by inhibiting the growth and division of cancer cells,so as to alleviate symptoms and prolong survival.At the same time,chemotherapy also has many side effects,which can cause a series of side effects such as malnutrition and inflammation.Severe side effects can lead to poor outcome of chemotherapy and affect the prognosis of patients.Studies have shown that Omega-3 polyunsaturated fatty acids can improve malnutrition,regulate inflammatory response and prevent complications in these patients.However,it has been found in a number of related clinical studies that its effect on the efficacy of tumor chemotherapy is still controversial.In this study,meta-analysis was used to analyze the efficacy of Omega-3 polyunsaturated fatty acids in chemotherapy patients,in order to provide a clearer and more comprehensive understanding.Methods: We search Pub Med,Embase,Cochrane library and Web of Science databases.From the establishment of the database to December 2022,all randomized controlled trials of the effects of Omega-3 polyunsaturated fatty acids on nutritional status and inflammatory response in chemotherapy patients were collected.According to the inclusion and exclusion criteria,the literature was selected,the data were extracted and the quality was evaluated.Meta-analysis was performed by Revman5.3and STATA 15.0 software,and subgroup analysis was made on sample size,Jadad score,study area,tumor location,Omega-3 polyunsaturated fatty acid type,dose,dosage form and treatment time.Results: We have retrieved totally 510 articles,most of which are high quality.After screening,18 randomized controlled trials were included,with a total of 814 patients.The results of meta-analysis showed that the body weight(MD=1.24,95%CI:0.55～1.93,P=0.0004),albumin(SMD=0.37,95%CI: 0.09～0.65,P=0.009)and C-reactive protein(SMD=-0.9,95%CI:-1.21 ～-0.60,P<0.00001)of Omega-3polyunsaturated fatty acid experimental group were significantly higher than those of the control group,and the difference was statistically significant.However,the levels of IL-6(SMD=-0.11,95%CI-0.38～0.16,P=0.425>0.05)and TNF-α(SMD=-0.09,95%CI-0.31～0.14,P=0.449>0.05)were not affected,and the difference was not statistically significant.At the same time,oral Omega-3 polyunsaturated fatty acid supplements can also reduce the incidence of adverse events(RR=0.66,95%CI0.49～0.9,P=0.008).Conclusions: Supplementation of Omega-3 polyunsaturated fatty acids can improve the nutritional status of chemotherapy patients,inhibit systemic inflammatory reaction,reduce the incidence of adverse events and prevent complications.