Self-enriched Platelet Plasma Intervention Cycle Irrigation Combined With Radio Frequency Ablation Treatment Of Clinical Effects Observation Of Disk Source Back Pain

Objective:In this study,we aimed to explore the efficacy of autologous platelet-rich plasma(PRP)combined with radiofrequency thermocoagulation(RFT)in the treatment of discogenic low back pain(DLBP).Methods:All patients with disc-induced low back pain diagnosed in the Department of Rehabilitation Medicine of the Second Affiliated Hospital of Nanchang University from January 2020～November 2022 were selected as the study subjects,and randomly divided into control group and observation group.The control group was treated with interventional perfusion by radiofrequency ablation alone,and autologous PRP combined with radiofrequency ablation interventional perfusion therapy was given in the observation group.According to statistics,the total number of patients diagnosed with low back pain in our hospital is about 158,including 134 patients who meet the inclusion criteria and 24 patients who meet the exclusion criteria.Among the 134 patients who met the inclusion criteria,the number of patients who underwent radiofrequency ablation alone interventional perfusion therapy was 65,of which 3 were lost to follow-up,and the number of cases in the control group actually completed the study was 62.The number of patients treated with radiofrequency ablation combined with autologous PRP interventional perfusion was 69,of which 5 were lost to followup,and the number of cases in the observation group actually completed the study was64.The pain score(VAS score)and functional impairment index(ODI index)of the two groups before and after treatment were observed 4 weeks and 8 weeks after treatment,and the efficacy was evaluated 4 weeks and 8 weeks after surgery.Observe the changes in lumbar disc MRI before and after treatment in some patients Results:The differences in the Visual Analog Scale(VAS)scores and the Oswestry Disability Index(ODI)between the observation group and the control group before the treatment were not statistically significant(P > 0.05 in both).However,four weeks and eight weeks after the treatment,the VAS scores and the ODI were significantly lower in both groups than those before the treatment(P < 0.05 in both).In terms of the therapeutic efficacy,eight weeks after the treatment,the total effective rates in the control group and the observation group were 67.7% and 87.5%,respectively,with the observation group being superior to the control group(P < 0.05).Conclusion:Autologous PRP perfusion using an IMCS combined with RFT is a safe and effective treatment for DLBP,and it had superior long-term effects in improving clinical symptoms and patient dysfunction than the use of RFT alone.