Clinical Observation On The Treatment Of Premature Ovarian Insufficiency By One-source And Three-branch Theory Acupuncture

Objective: To investigate the therapeutic efficacy and feasibility of one-source and three-branch theory acupuncture in the treatment of patients with premature ovarian insufficiency,including serum basal follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),anti-Muller-tube hormone(AMH),and the number of sinus follicles(AFC).Methods: A total of 100 patients who met the clinical diagnosis of early onset ovarian insufficiency were selected from the Premature Ovarian Failure Studio of Gynecology Department,Xiangyang Hospital of Traditional Chinese Medicine,Hubei Province from December 2021 to May 2022.They were divided into acupuncture test group and western medicine control group by simple random number table method,with 50 cases in each group.Acupuncture treatment group selected acupoints according to the theory of one source and three channels.Acupuncture was performed at Taichong point(bilateral)of Chong pulse,Qi Hai,Guan Yuan,Zhong Ji,Qugu and other points of Ren pulse,Mingmen point and Baihui point of Du pulse,Sanyinjiao point of Foot Taiyin and Spleen meridian(bilateral),and uterus point(bilateral)were selected locally.After receiving Qi,patients were left with needles for 30 minutes by means of lifting and inserting and twisting and purging techniques.Once every 2 days,10 times for a course of treatment.Western medicine control group was given sequential therapy of estrogen and progesterone combined with ovulation promoting drugs.Patients were instructed to take oral bujia 1mg/ time once a day for 21 days starting from the third day of menstrual cycle.Letrozole tablets,2.5mg/ time,once a day for 5 days;After follicular monitoring by color doppler ultrasound,progesterone was appropriately supplemented,and progesterone capsules were taken orally 100mg/ time,once a day,for 10 days.After suspension of medication,the patient’s physical condition was evaluated to observe whether FSH,LH,FSH/LH,E2,AMH,AFC and other indicators were improved.Results: The total clinical effective rate of the western medicine control group was 54%,which was lower than that of the acupuncture experimental group(86%),and there was statistical difference between the two groups(P<0.05).Compared with before treatment,serum E2 and AMH levels in 2groups were increased after treatment(P < 0.05),and compared with western medicine control group,FSH and LH in experimental group were decreased more significantly(P < 0.05).Color ultrasound examination after treatment showed that AFC in both groups was increased compared with that before treatment(P<0.05),and that in the experimental group was increased more than that in the western medicine control group(P<0.05).Conclusion: One-source and three-branch theory acupuncture treatment can effectively improve the sex hormone disorder in patients with early-onset ovarian insufficiency,reduce the clinical symptoms related to perimenopause,improve ovarian reserve function,promote ovulation and change pregnancy outcome.