A Study On Function And Plasticity Of Binocular Visual Perception In Myopia

Objective:This study quantify binocular imbalance(BI)to establish the basis of a biological model of visual perceptual impairment in early myopia and explore a new approach for myopia screening and myopia control.Methods:(1)Part 1 is a cross-sectional study involving a total of 160 subjects.The myopic group and the non-myopic group had 80 subjects,respectively.All subjects underwent BI value test after mydriatic refraction.(2)Part 2 is a prospective case analysis,including 40 subjects.All 40 subjects underwent BI value test(baseline)after collecting ocular biometric data and mydriatic refraction,and which would be reviewed after 6 months.(3)Part 3 is a randomized controlled trial,including60 subjects.The training group and the control group had 30 subjects,respectively.BI value is measured at baseline,10 minutes later,and 3 months later,respectively in the two groups.Results:(1)There is no statistical difference of the BI proportion between myopic and non-myopic group(χ2=0.196,P =0.658).either the BI value between myopic and non-myopic group(P =0.41).There are no correlations shown between spherical equivalent(SE)and BI values(P>0.05 in all the groups).(2)The correlations between BI value and SE progression in 6 months are: OD:R=0.794,P =0.000;OS: R=0.684,P =0.000.In the logistic regression model of SE progress,the OR values of BI in baseline are OD: 1.210(95%CI:1.067-1.374),P=0.003 and OS: 1.180(95%CI:1.064-1.309),P=0.002,respectively.(3)The changes of BI value between the two groups from baseline measurement to measuring point 1a/1b are:(-4.67±6.15)in training group and(0.67±2.54)in control group,P <0.001;From baseline measurement to measuring point 2:(-15.50±15.22)in training group and(0.17±5.94)in control group,P <0.001.Conclusions: There is no significant correlation between myopia status and BI value measured in the same period.Whereas BI value is significantly correlated with the myopia progress in six months,and is indicated as the risk factor for fast myopia progress,which means BI has the potential to become a warning indicator for myopia.Moreover,BI as a visual functional defection has a plasticity feature,which can be significantly improved after visual perception training.