Analysis Of Clinical Characteristics In 285 Patients With Bronchiectasis

Objective:In recent years,the incidence and prevalence of bronchiectasis reported internationally have gradually increased,while the epidemiological data of bronchiectasis are lacking in China,the domestic attention to it is low and the progress of related studies is slow.By summarizing the clinical characteristics of 285 patients with bronchiectasis and reviewing the related literature,we aim to improve the clinical understanding and diagnosis and treatment of bronchiectasis.Method:In this study,285 patients with bronchiectasis diagnosed in the Department of Respiratory Medicine of the Second Clinical College of Jinan University from January 2020 to December2020 were collected and their age,gender,disease duration,clinical symptoms,etiological classification,sputum microbiology,imaging,pulmonary function and other data were retrospectively analyzed.Results:1.In terms of general baseline data,among the 285 patients with bronchiectasis,there were 119 males and 166 females,with the highest proportion of patients aged 51～60(25.26%).The proportion of men who smoke is significantly higher than that of women,with a statistically significant difference(P<0.05).2.In terms of clinical manifestations,the age of onset was(55.83±17.33)and(53.29±16.38)years for male and female patients respectively,with cough(34.9%),expectoration(32.6%)and hemoptysis(16.5%)as the main clinical manifestations.3.In terms of comorbidities,the proportion of patients with hypertension was the highest(14.74%),followed by chronic obstructive pulmonary disease(5.96%)and rhinitis(8.07%).4.In terms of the etiology of bronchiectasis,45.60% of patients with branched enlargement had a definite cause,with infection being the most common cause of branched enlargement(35.44%),including 34 cases of previous infection,accounting for 33.66% of patients with post-infectious branched enlargement;This was followed by other airway diseases,including chronic obstructive pulmonary disease(2.46%)and asthma(1.40%).5.In terms of etiology,91 patients with bronchiectasis had positive sputum culture results(31.93%),of which 60 were Gram-negative bacteria,the most common causative organism being pseudomonas aeruginosa,followed by Mycobacterium tuberculosis.6.In terms of imaging,279 patients underwent HRCT of the chest,with the highest proportion of patients with columnar dilatation type(69.53%)and the highest proportion of lesions in the middle lobe of the right lung(65.96%),followed by the lower lobe of the left lung(60.35%).7.In terms of pulmonary function,pulmonary ventilation was performed in 77 patients and diffusion function was performed in 36 patients,The expected FVC predicted value(%)were lower and statistically significant(P<0.05)for patients with cystic and varicose veins than for those with columnar forms;history of asthma,a high number of acute exacerbations,a high Reiff score,and infection with PA were associated with lower FEV1 predicted values(%)(P< 0.05).Conclusions:Patients with bronchiectasis in this study were predominantly middle-aged and elderly,with a significantly higher proportion of men than women smoking;previous infections were the most common cause of bronchiectasis,with pseudomonas aeruginosa being the most common bacterium;pulmonary impairment was more severe in cystic and varicose bronchiectasis than in columnar bronchiectasis,and imaging findings of this type of bronchiectasis warranted attention.;and Impaired lung function is associated with history of asthma,high number of acute exacerbations,high Reiff score,and infection with pseudomonas aeruginosa.