The Correlation Analysis Between Sarcopenia And Cognitive Impairment In Elderly Population

ObjectivesSarcopenia and cognitive impairment in older adults are related to many adverse health outcomes,which seriously affect the quality of life of older adults and cause huge medical and socio-economic burden.The purpose of this study is to understand the situation of sarcopenia and cognitive impairment in older adults in Fuzhou,and to analyze the relationship between sarcopenia and cognitive impairment in older adults.MethodThe eligible older adults aged 60 and above who were treated or examined in Fujian Provincial Hospital between June 2020 and December 2020 were selected as the target population.The basic data of the subjects,physical examination,laboratory examination were collected;muscle quality,muscle strength and muscle function were assessed by double-energy X line examination,grip force and step measurement;the Montreal Cognitive Assessment Scale(Mo CA)was used to assess cognitive function.The research subjects were divided into sarcopenia group and non-sarcopenia group according to the 2019 Asian sarcopenia consensus on sarcopenia.Univariate and multivariate logistic regression analyzed the correlate factors in sarcopenia.KruskalWallis H test compared Mo CA evaluation of the elderly people in different age groups.The proportion of cognitive impairment at different ages was analyzed by the Chisquare test for trend.Univariate and multivariate logistic regression analyzed the factors associated with impaired cognitive function.Class II logistic regression were used to analyze the relationship between sarcopenia and cognitive impairment.Compared the levels of muscle mass,muscle strength and muscle function between groups of different levels of cognitive function;and compared the proportion of impaired cognitive function at different levels of muscle mass,muscle strength,and muscle function.Class II logistic regression were used to analyze the relationship between muscle quality,muscle strength,muscle function and cognitive impairment.Result1.A total of 151 elderly ≥60 years old were collected in this study,including 41 patients with sarcopenia(26.6%)and 58 patients with impaired cognitive function(38.4%).2.Multivariate logistic regression analysis showed that the older the elderly,the higher the risk of sarcopenia(OR>1,P<0.001).3.Kruskal-Wallis H test showed significant difference between Mo CA score and age(P<0.05),Mo CA scores decreased with aging.The Chi-square test for trend found that the proportion of cognitive impairment increased with age(P<0.05).4.Multivariate logistic regression analysis showed that the older the elderly,the higher the risk of cognitive impairment,the elderly with lower education levels had a higher risk of cognitive impairment(OR < 1,P<0.01),and the elderly with lower albumin levels are more likely to have cognitive impairment(OR<1,P<0.05).5.Class II logistic regression analysis found that there was no significant correlation between sarcopenia and cognitive impairment in elderly adults(P>0.05).6.There were significant differences in muscle mass(P < 0.001),muscle strength(P < 0.001)and muscle function(P < 0.01)between the cognitive impairment group and the cognitive normal group.The proportion of cognitive impairment increased in the group with decreased grip strength,(P < 0.05).7.Class II logistic regression analysis showed that the lower the muscle strength of elderly adults,the greater the risk of cognitive impairment(OR<1,P<0.05).ConclusionAmong the subjects of this study,the prevalence of sarcopenia and cognitive impairment in the elderly was 26.6% and 38.4%.The older the elderly,the higher the risk of sarcopenia.The risk of cognitive impairment increases with aging.The lower the level of education,the lower albumin levels and the higher risk of cognitive impairment.There was no significant correlation between sarcopenia and cognitive impairment among the subjects of this study.However,muscle strength was negatively associated with the risk of cognitive impairment in older adults.