Effect Of Diabetes On Cartilage Degeneration In The Knee

Objective: To analyze the effect of diabetes on the morphology and biochemical composition of knee cartilage was investigated by MRI of knee cartilage in diabetic patients.Methods: From November 2020 to November 2021,45 patients who underwent bilateral MRI of the knee joint at the First Hospital of Jinan University were divided into 15 patients with non-DM,11 patients with primary DM and 19 patients with long-term DM according to their DM status and duration of disease.MRI,T2 WI,3D-SPGR and DWI details were recorded using R software for statistical analysis.One-way ANOVA,rank sum test were used to analyse the data between groups and paired t-test was used to analyse the follow-up data,P<0.05 indicates a statistically significant difference.Results:(1)Patients with DM in the primary group had good glycemic control during followup,with a statistically significant difference(P<0.0001);glycemic control in the primary group before follow-up was worse than that in the long-term group,with a statistically significant difference(P<0.01);glycemic control during follow-up in the primary group was not statistically significantly different from that in the long-term group(P =0.18);(2)Thickness: the cartilage of the medial femoral condyle was thinner in the non-DM group compared with the primary group,and the difference was statistically significant(P<0.01);the cartilage of the patellar surface,medial femoral condyle and medial tibial condyle was thicker in the non-DM group compared with the long-term group,and the difference was statistically significant(P<0.0001);the cartilage of the patellar surface,femoral condyle and medial tibial condyle was generally thicker in the primary group compared with the long-term group,and the difference was statistically The difference was statistically significant(P<0.05);the medial femoral condyle became thinner after follow-up in the primary group(P<0.001);(3)Degeneration grading: the Recht grading of cartilage on each articular surface was not statistically different in the non-DM group compared with the primary group;the Recht grading of medial femoral condyle and medial tibial condyle was lower in the non-DM group compared with the long-term group,and the difference was statistically significant(P<0.05).The difference between the non-DM group and the long-term group was statistically significant(P<0.05);the difference between the medial femoral condyle and medial tibial condyle was statistically significant(P<0.05);the difference between the Recht classification before and after follow-up was not statistically significant;(4)ADC values: the ADC values of patellar surface,medial femoral condyle and medial tibial condyle were lower in the nonDM group compared with the long-term group.The difference was statistically significant(P<0.05);the cartilage ADC values of patellar surface,femoral condyle and medial tibial condyle were lower in the non-DM group compared with the long-term group,and the difference was statistically significant(P<0.05);the cartilage ADC values of patellar surface,medial femoral condyle and medial tibial condyle were also lower in the primary group compared with the long-term group,and the difference was statistically significant(P<0.05);the ADC values of the patellar surface,medial femoral condyle and medial tibial condyle in the primary group decreased after follow-up,and the difference was statistically significant(P<0.05);the ADC values of the patellar surface,medial femoral condyle and medial tibial condyle in the primary group were ADC values decreased compared to those before,with a statistically significant difference(P<0.001).Conclusion:(1)There was a positive correlation between the duration of DM disease and KOA cartilage degeneration,and the cartilage degeneration in the medial compartment of the knee joint was severe in DM patients;(2)Good glucose management can improve cartilage permeability in DM patients to some extent;(3)MRI has important diagnostic value for early KOA cartilage degeneration.