Correlation Analysis And Prediction Model Of HALP,MRR And Postoperative Prognosis Of Hepatocellular Carcinoma

Objective:To detect preoperative liver function and blood routine indexes,and to calculate preoperative Hemoglobin,Albumin,Lymphocyte,and Platelet(HALP)and monocyte-to-red blood cell ratio(MRR)in patients with primary hepatocellular carcinoma(HCC).And included the classical indicators Neutrophil-to-Lymphocyte Ratio(NLR).To investigate the clinical value of HALP,MRR and other indicators in predicting postoperative prognosis of primary hepatocellular carcinoma.Methods: According to the confirmed inclusion and exclusion criteria,patients hospitalized in the Department of Hepatobiliary Surgery of the First Affiliated Hospital of The University of South China from January2015 to December 2018 who received hepatocellular carcinoma with pathological results were enrolled as subjects.Relevant laboratory indicators,such as blood routine,liver function,Alpha Fetal protein(AFP),total bilirubin,and prothrombin time,were collected one week before surgery.Relevant clinicopathological parameters,such as tumor length,tumor differentiation,tumor stage,presence or absence of vascular tumor thromboluspresence or absence of microvascular invasion,presence or absence of satellite nodules,and surgical conditions,such as open or laparoscopic surgery,and presence or absence of intraoperative and postoperative blood transfusion.Patients were followed up by consulting their hospitalization information and telephone interviews,with the minimum follow-up time of 3 years and the end point of follow-up on December 30,2021.The 1-year and 3-year survival rates were calculated according to the follow-up end points,and univariate and multifactorial survival rates were analyzed by COX regression model.Finally,a prediction model based on independent prognostic factors was established and the correlation tests were carried out.Results:1.COX univariate analysis of liver cancer prognosis showed that HALP,MRR,NLR,microvascular invasion,tumor length and tumor stage were statistical significance(P<0.05)2.COX multivariate analysis of prognosis of liver cancer showed that HALP,NLR,tumor length and tumor stage were statistically significant(P<0.05)3.The prediction model based on HALP and NLR has good differentiation,calibration and clinical practicability.Conclusion:1.HALP,NLR,tumor diameter and tumor stage are independent prognostic factors for 3-year postoperative survival of HCC patients,which may have the role of evaluating postoperative prognosis of HCC.2.MRR was not proved to be a predictor of postoperative prognosis of HCC patients in this study.3.The prediction model based on HALP and NLR has good prediction efficiency and clinical application value for the prediction of postoperative survival rate of hepatocellular carcinoma.