Correlation Between Endometrial Intraepithelial Neoplasia,Endometrial Adenocarcinoma And Vaginal Microecology

Background:Endometrial cancer（EC）is one of the three most common malignant tumors in the female reproductive system,the sixth most common cancer in the world,and ranks fourth in the incidence of malignant tumors in the female population.Data from China’s National Cancer Medical Research Center show that the incidence of endometrial cancer is second only to cervical cancer,and with the rapid development of population aging,its incidence and mortality rate have increased,seriously threatening female reproductive health,as of now,but the mechanism of endometrial cancer is still not very clear.In recent years,it has been thought to be associated with the state of the reproductive tract flora.Objective:To understand the status of the vaginal microecology of endometrial endothelial tumors and endometrial cancer patients,and to explore whether there is a correlation between endometrial cancer and vaginal microecology.Methods:A total of 185 samples were analyzed from September 2019 to December 2021 in gynecological patients in the First Affiliated Hospital of Henan University of Science and Technology,and their vaginal microecological samples were collected.A total of 185 samples were analyzed,including 68 samples from the control group and samples from the case group.117.Among the 117 cases,55 were diagnosed as endometrial intraepithelial neoplasia and 62 were diagnosed as endometrial cancer;the control group was selected from healthy patients with normal vaginal microecology during the same period.Comparison of vaginal flora density,flora diversity,vaginal p H,Nugent score,white blood cells/oil lens,Leukocyte esterase,sialidase,hydrogen peroxide,etc.The chi-square test and logistic regression multivariate correlation analysis were used to determine the correlation between the occurrence of endometrial intraepithelial neoplasia and endometrial cancer group and vaginal dysbiosis.Results:In the comparative analysis of EC group and control group,p H value,H₂O₂,Nugent score,white blood cells/oil lens,flora density,Lactobacillus,Gram-negative Brevibacterium were statistically significant（p<0.05）,sialidase and There was no statistical significance between leukocyte esterases（p>0.05）;in the comparative analysis of EIN group and control group,p H value,H₂O₂,Nugent score,flora density,Lactobacillus,Gram-negative Brevibacterium were statistically significant（p<0.05）,while there was no statistical significance among the other three factors（p>0.05）.In the multivariate logistic regression analysis,it can be concluded that p H value and H₂O₂ are the risk factors of the disease,and the density of flora is the protective factor of the disease.Conclusion:There is a correlation between vaginal microecological imbalance and endometrial cancer,and the abnormal microenvironmental factors p H value and H₂O₂ suggest that it is a risk factor for the disease,and the density of flora is a protective factor for the disease.Maintaining microecological balance is meaningful for patients with endometrial cancer,but its causal relationship needs to be verified by further experimental studies.