Preliminary Study Of Coronary Heart Disease Was Evaluated By The Application Of CCTA Derivatives Coronary Week Fat Attenuation Index And CT Blood Accumulation Score Fraction

Objective:The quantitative assessment of pericoron fat and blood float reserves used to be carried out through CCTA-derived FAI and FFR_CT,and the clinical association between perivascular fat,blood flow reserves and coronary atherosclerosis used to be in addition clarified,with a view to exploring and evaluating new technologies for the detection of coronary atherosclerosis diseases and providing a groundwork for the accurate diagnosis and treatment of CHD.Methods:The CCTA records of 175 patients with suspected high-risk CHD had been retrospectively analyzed,and the parameters of coronary artery stenosis,plaque type,plaque composition,perivascular FAI,perivascular LDDDF,and FFR_CThad been measured and calculated,and the above parameters had been correlated with the above parameters.Statistical treatment included analysis of variance,subject work characteristic curve,correlation analysis,P<0.05 believe that the difference is statistically significant.Results:There was no significant difference between normal and diseased perivascular FAI（P=0.725）.There was statistically significant difference between normal and diseased perivascular LDDDF（P<0.05）.There were statistically significant differences in FAI and LDDDF between non-calcified plaque and mixed plaque and calcified plaque（P<0.05）.There was statistically significant difference between non-calcified plaque and calcified component mixed plaque（P<0.05）in the comparison of perivascula LDDDF in vascular wall plaque.There were statistically significant differences between the calcified plaque and the mixed plaque with calcified and non-calcified components and the mixed plaque with non-calcified components（P<0.05）.Perivascula FAI（-81.9±7.2HU vs.-84.3±7.6HU,t=2.845,P<0.05）and perivascula LDDDF（-43.8±26.4vs.-24.6±22.9,t=7.167,P<0.05）were mainly composed of lipid cored fiber fat and fiber calcified,the differences were statistically significant;Perivascula FAI（-82.8±7.4HU vs.-85.2±7.8HU,t=-3.160,P<0.05）and perivascula LDDDF（-19.4±21.5vs.-35.6±25.4,t=6.881,P<0.05）were compared between high-risk plaque and non-high-risk plaque,the differences were statistically significant.The degree of coronary artery stenosis was significantly negatively correlated with FFR_CTvalue（r=-0.714,P<0.05）.FFR_CTof normal coronary artery and lesion lumen showed statistically significant difference（P<0.05）.FFR_CTof the coronal FAI≤-70HU group and the coronal FAI>-70HU group were significantly different（P<0.05）.The AUC area of perivascula FAI and perivascula LDDDF for predicting plaque vulnerability was0.58 and 0.711（P<0.05）,respectively.The high-risk characteristics,plaque type,stenosis degree,FAI value,LDDDF value and FFR_CTvalue were highly consistent in the detection of coronary heart disease（Kendall W=0.805,P<0.05）.Conclusion:The changes of FAI and LDDDF are clinically correlated with the degree of vulnerable plaque and myocardial ischemia,suggesting that CCTA-derived FAI,LDDDF and FRR_CTcan further classify vulnerable plaque and myocardial ischemia,and are potential new indicators for predicting MACE.