Evaluation Of Antimicrobial Agents For Perioperative Prophylaxis Of Ⅰ Incision

Objectives By investigation of the application and the rationality of antimicrobial agents using perioprative in type I incision surgery,and the study the influence of factors on the orthopaedic postoperative rehabilitation,furthermore,the rationality of the application of antibiotics in perioperative incision I was evaluated,and the pharmaceutical intervention strategies were proposed according to the influencing factors to increase the enthusiasm of pharmacists to participate in the surgical treatment and to provide evidence for clinical rational drug use.Methods A total of 11061 cases of inpatients undergoing orthopedic surgery in a thirdgrade A hospital were collected from January 1,2019 to June 30,2021.By the collection of basic patient information,operative information and perioperative medication information.t test,F test,univariate and multivariate Logistic regression analysis were used to analyze the factors,predict the evaluation model and verify the results.After extensive factor analysis,modeling of perioperative antibiotics use was reintroduced to study the relationship between perioperative antibiotics use and postoperative prognosis,and statistical analysis of treatment cost was conducted.Results Gender,age,type of operation,site of operation,high risk group,time of operation,time of anesthesia,type of anesthesia and use of analgesic drugs can affect the recovery of patients after orthopedic surgery.The influencing factors of length of hospital stay included gender OR[95%CI]=1.05[1.01,1.16],age OR[95%CI]=1.00[1.00,1.01],organ surgery OR[95%CI]=0.79[0.65,0.97],time of operation OR[95%CI]=1.01[1.01,1.01],time of anesthesia OR[95%CI]=1.00[1.00,1.00],intravenous inhalation combined anesthesia OR[95%CI]=1.11[1.09,1.12],opioid analgesics alone OR[95%CI]=1.48[1.40,1.57],with all P<0.05;The influencing factors of discharge VAS score included opioid analgesics alone and high-risk group,With all P<0.05.VAS score at 3 months was correlated with intravenous inhalation combined anesthesia,duration of surgery,opioid analgesics alone and vertebral surgery at surgical site,with all P<0.05.The influencing factors of adverse reactions in patients included gender OR[95%CI]=1.31[1.07,1.40],time of anesthesia OR[95%CI]=1.35[1.03,1.52],high-risk population OR[95%CI]=1.31[1.10,1.41],perioperative antibiotic application OR[95%CI]=1.96[1.35,2.47],intravenous inhalation combined anesthesia OR[95%CI]=1.58[1.17,1.78],opioid analgesics alone OR[95%CI]=1.49[1.08,1.58],With all P<0.05.The use of perioperative antibiotics during reintroduction and rationality of antibiotics(OR[95%CI]=1.17[1.11,1.23],P<0.05)were related to the recovery rate of patients in 3 months.Meanwhile,surgical site,body position,type,anesthesia time and operation time could affect the treatment cost,With all P<0.05.Conclusions Reducing the use of perioperative antibiotics can reduce the adverse reactions of class I incision surgery to a certain extent,improve the efficacy of patients,and reduce the treatment cost.The recovery rate of the patients could be improved by the rationality of using perioperative antibiotics.Figure 4;Table 21;Reference 112...