The Clinical Observation On The Efficacy Of Modified Sanhuang Xuejie Ointment In The Treatment Of Diabetic Foot With Damp Heat And Toxin Excess Syndrome

Objectives To observe the improvement of Sanhuang Xuejie ointment on the clinical symptoms of diabetic foot with damp heat and toxin excess syndrome,and to explore the effect of Sanhuang Xuejie Fang ointment on inflammatory indexes.Methods This study selected 60 diabetic foot patients who met the inclusion and exclusion criteria in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Province,and randomly divided them into a control group and a treatment group,30 people in each,the control group received basic treatment + lactic acid Saacridine solution gauze external application for treatment,the treatment group was given basic treatment + Sanhuang Xuejie ointment(15g Coptis chinensis,15 g Cortex Phellodendri,15 g Rhubarb,6g Xuejie,15 g Lithospermum,6g Atractylodes Rhizoma,6g Achyranthes sichuanensis,15 g Chishao)External application of gauze was used for 4weeks.Observe the changes of TCM syndrome scores,wound area,and inflammatory indexes before and after the treatment,and whether they appear during treatment adverse events.Statistical software SPSS 26.0 was used for statistical analysis of the research results.When P < 0.05,it was considered to be statistically significant.Results A total of 60 patients were selected in this study.During the study,1 patient in the experimental group dropped out due to loss to follow-up,and 1 patient in the control group was excluded because the self-purchased topical drug applied to the affected area interfered with the test results.After the test,58 cases were actually completed,29 cases in the treatment group and 29 cases in the control group.Before the test,the gender,age,duration of diabetes mellitus(DM),duration of diabetic foot(DF),fasting blood glucose(FPG),2-hour postprandial blood glucose(2h PG),and glycosylated hemoglobin(Hb A1c)were compared between the two groups of patients.),albumin(ALB),hemoglobin(Hb),cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),TCM syndrome score,wound area,high-sensitivity C-reactive protein(hs-CRP),erythrocyte sedimentation rate(ESR)and interleukin-6(IL-6)were statistically analyzed,and there was no statistical difference(P > 0.05).1 TCM syndrome scores: After treatment,the TCM syndrome scores of the two groups were decreased(P < 0.05),and the curative effect of the treatment group was better than that of the control group(P < 0.05).2 TCM syndrome and main syndrome score: after treatment,the improvement of TCM syndrome score and main syndrome score in the treatment group was better than that in the control group(P < 0.05).3 TCM syndrome sub-syndrome score: the treatment group has a statistical difference in improving pain and reducing tendon swelling compared with the control group(P < 0.05),while in the treatment of fever,thirst,irritability,constipation,and redness,the two groups are compared There was no statistical difference(P > 0.05).4 The efficacy of TCM syndrome score: the total effective rates of the treatment group and the control group were89.67%(26 cases)and 75.86%(22 cases),respectively,and the two treatment programs had a statistical difference in reducing the TCM syndrome score(P < 0.05).5 Wound area:The wound area of the two groups of patients after treatment was smaller than that before treatment(P < 0.05),and the treatment group was better than the control group(P < 0.05).6 Wound area healing rate: There was a statistically significant difference in the wound area healing rate between the two treatment methods(P < 0.05).7 Inflammatory indexes:hs-CRP,ESR and IL-6 in both groups after treatment were lower than those before treatment(P < 0.05),and the reduction of hs-CRP,ESR and IL-6 levels in the treatment group was significantly better than that in the control group(P < 0.05).8 Before and after treatment,there were no significant differences in blood glucose,blood lipids,ALB,and Hb between the two groups(P > 0.05).There were no adverse events in the two groups of patients during the treatment.Conclusions 1 Sanhuang Xuejie ointment has obvious advantages in improving the TCM syndromes of DF patients with damp heat and toxin excess syndrome,and can effectively improve the local clinical symptoms of patients.2 Sanhuang Xuejie ointment can promote wound repair and accelerate wound healing.3 Sanhuang Xuejie ointment can significantly reduce the levels of inflammatory indexes such as hs-CRP,ESR,IL-6.Figure0;Table12;Reference 124...