Correlation Between SdLDL-C、Non-HDL-C、Hcy And The Acute Ischemic Stroke

BackgroundIschemic stroke refers to a general term for brain tissue necrotic diseases caused by stenosis or occlusion of the blood supply artery of the brain and insufficient blood supply to the brain.Acute ischemic stroke is the most common type of stroke,and the acute phase generally refers to disease develops within two weeks after onset.Atherosclerosis is the main pathogenic mechanism leading to ischemic stroke,and dyslipidemia is the leading cause of atherosclerosis.Analysis of the relationship between small dense low-density lipoprotein cholesterol(sdLDL-C),non-high-density lipoprotein cholesterol(Non-HDL-C)levels and acute ischemic stroke,can provide experimental basis for the prevention and adjuvant treatment of acute ischemic cerebrovascular diseases.ObjectiveTo analyze the correlation between sdLDL-C,Non-HDL-C and Hcy levels and acute ischemic stroke,and to improve the predictive mechanism of stroke occurrence,and to provide a more effective prevention strategy for acute stroke.MethodsAccording to the standard,393 cases of hospitalization or physical examination in Henan Provincial People’s Hospital were collected and divided into three groups.In the experimental group,131 patients were diagnosed as acute ischemic stroke,including 83 males and 48 females,aged 26-87 years,with an average age of 58.3±13.1 years.132 patients in the control group A were diagnosed as hemorrhagic stroke patients,including 73 males and 59 females,aged 21-83 years,with an average age of 56.5±14.2 years.There were 130 healthy controls,73 males and 57 females,aged 24-85 years,with an average age of 53.5±14.1 years.There were no history of cardiovascular and cerebrovascular diseases,hypertension and diabetes in the healthy control group.The blood biochemical indicators were basically normal.The three groups of subjects in the experiment required fasting venous blood collection,and then sdLDL-C was detected by peroxidase method,and levels of six lipids(TG,TC,HDL-C,LDL-C,Apo A-Ⅰ,Apo B100)and homocysteine(Hcy)were detected by automatic biochemical analyzer.Statistical analysis of data was performed using SPSS23.0.The results of the measurement data were used to show that the comparison between the data of multiple groups was analyzed by using the variance,and the difference between the groups was statistically significant with the t test by P < 0.05.Unconditional multivariate logistic regression analysis was performed for whether the acute ischemic stroke was the dependent variable,sdLDL-C,Non-HDL-C and Hcy were independent variables.Using the sensitivity and specificity of sdLDL-C,Non-HDL-C and Hcy indicators to map the receiver’s work characteristic curve(ROC curve)for acute ischemic stroke patients,hemorrhagic stroke patients and The detection indexes of the three groups in the healthy control group were statistically analyzed.Results1.Compared with the healthy control group,the serum concentration of sdLDL-C in the experimental group was significantly higher than that in the hemorrhagic stroke control group,and the difference was statistically significant(P<0.05).2.The concentration of Non-HDL-C in the experimental group was significantly higher than that in the healthy control group,and the difference was statistically significant(P<0.05).Compared with the hemorrhagic stroke control group,the concentration of Non-HDL-C in serum was increased.The difference was statistically significant(P<0.05).3.Compared with the healthy control group and the hemorrhagic stroke control group,the serum Hcy concentration in the experimental group was significantly increased,the difference was statistically significant(P<0.05).4.Compared with the healthy control group,the concentration of Non-HDL-C and Hcy in the hemorrhagic stroke control group increased significantly,the difference was statistically significant(P<0.05);while the difference in sdLDL-C expression was not statistically significant.Academic significance(P>0.05)5.Logistic regression analysis showed that serum sdLDL-C,non-HDL-C,and Hcy were independent risk factors for acute ischemic stroke,and HDL-C was a protective factor for ischemic stroke.6.The ROC curve analysis showed that serum sdLDL-C,non-HDL-C,Hcy and LDL-C had certain clinical significance in the diagnosis of ischemic stroke,and the comprehensive value of serum Hcy was better,followed by non-HDL-C.The combined detection of sdLDL-C + non-HDL-C + Hcy is of greater value in the diagnosis of acute ischemic stroke.ConclusionCompared with the four items of conventional blood lipid detection,the combined detection of serum sdLDL-C,Non-HDL-C and Hcy has certain guiding significance for early prediction,auxiliary diagnosis and differential diagnosis of acute ischemic stroke.