| Objective:Based on the mesh meta-analysis method,this paper studied the efficacy and safety of external treatment of traditional Chinese medicine in the treatment of breast cancer fatigue,conducted a systematic evaluation,compared the differences in the efficacy of different treatment schemes,and screened out a possible best treatment scheme to provide reference and evidence-based medical evidence for the selection of clinical treatment schemes.Methods:According to the corresponding search strategy,data retrieval was conducted in databases(Chinese including CNKI database,Wanfang database,Chongqing VIP database,English including Cochrane Library,CSIE database,Pub Med),and randomized controlled trials(RCTS)related to the subject were screened and included.The search time was set from the establishment of the database to November 1,2022.Two researchers independently used the Cochrane risk bias assessment tool to evaluate the quality and risk bias of the included literature,and Review manager software was used for general meta-analysis.Stata software was used for network meta-analysis.Results: A total of 28 literatures were included in this study,all of which were Chinese literatures with publication years ranging from2011 to 2022.The number of literatures increased year by year,and a total of 1,951 patients were included.The results of general meta-analysis showed that external treatment of traditional Chinese medicine combined with conventional treatment had positive effects on reducing cancer-induced fatigue,improving the quality of life of patients with CRF,improving the sleep quality of patients with CRF,alleviating the anxiety and depression of patients with CRF.Basically confirmed the multi-dimensional improvement effect of external treatment of traditional Chinese medicine for breast cancer fatigue,but based on conventional treatment combined with external treatment of traditional Chinese medicine for cancer fatigue will increase the possibility of adverse events to a certain extent.The results of mesh meta-analysis showed that The curative effect of reducing cancer fatigue in patients with breast cancer is sorted as hot compress of traditional Chinese medicine+massage+conventional treatment>Tai chi+conventional treatment>Moxibustion+conventional treatment>five elements music therapy+conventional treatment>massage+conventional treatment>acupoint application+conventional treatment>Baduanjin+conventional treatment>ear point pressure bean+conventional treatment>Guasha+conventional treatment>acupuncture+conventional treatment>traditional Chinese medicine hot compress+conventional treatment>conventional treatment;The therapeutic efficacy of improving the qualityof life of CRF patients with breast cancer was ranked as moxibustion+conventional treatment>Tai Chi+conventional treatment>traditional Chinese foot bath+conventional treatment>auricular point pressure bean+conventional treatment>Gua Sha+conventional treatment>conventional treatment.The best treatment for improvingsleep quality of CRF patients with breast cancer was acupuncture+moxibustion+conventional treatment>acupoint application+conventional treatment>auricular point pressure bean+conventional treatment>Taijiquan+conventional treatment>Moxibustion+conventionaltreatment>acupuncture+conventional treatment>conventional treatment.The therapeutic efficacy of reducing anxiety of CRF patientswith breast cancer was ranked as Tai Chi+conventional treatment>Moxibustion+conventional treatment>acupoint application+conventional treatment>acupuncture+conventional treatment>conventionaltreatment.The therapeutic efficacy of reducing depression in patients with CRF breast cancer was ranked as Tai Chi+conventional treatment>Moxibustion+conventional treatment>acupoint application+conventional treatment>acupuncture+conventional treatment>conventional treatment.The safety of included treatment plans was ranked from high to low as conventional treatment>acupuncture+moxibustion+conventional treatment>acupuncture+conventional treatment>Gua Sha+conventional treatment=Tai Chi+conventional treatment>Moxibustion+conventional treatment.Conclusion: In conclusion,the combination of external traditional Chinese medicine(TCM)therapies with conventional therapies enhanced efficacy against breast cancer fatigue relative to conventional therapies alone with a tolerable safety profile.On the basis of conventional treatment,the best treatment for alleviating cancer fatigue in patients with breast cancer is traditional Chinese medicine heat compresses combined with Tuina,and the best intervention for improving the quality of life in patients with breast cancer CRF is moxibustion,and the best treatment for improving the quality of sleep in patients with breast cancer CRF is acupuncture combined with moxibustion,and the best intervention for alleviating anxiety and depression in patients with breast cancer CRF is Tai Chi,The intervention most likely to experience adverse events during treatment is moxibustion.After comprehensive analysis,it was found that Tai Chi holds promise as an intervention that can comprehensively improve breast cancer cause fatigue from multi dimensions. |
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