Clinical Study Of Paishi Decoction Combined With Tamsulosin Hydrochloride Sustained Release Capsules In The Treatment Of Ureteral Calculi (Lower Jiao Dampness And Heat Type)

Objective: In this study,by observing the changes of TCM syndrome score,calculi discharge rate,calculi discharging time and hydronephrosis degree before and after treatment of ureteral calculi(lower jiao dampness and heat type),to explore the clinical treatment of Paishi decoction combined with Tamsulosin hydrochloride sustained release capsules in the treatment of ureteral calculi(lower jiao dampness and heat type),which lays a corresponding foundation for the clinical promotion and application of Paishi decoction.Methods: A total of 80 subjects were included in this study,all of whom were from the outpatient Department of Urology of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from January 2022 to December 2022,and were clearly diagnosed as ureteral calculi(lower jiao dampness and heat type).They were divided into 2 groups according to random method,with 40 cases in each group,control group and treatment group.They were randomly divided into 2 groups according to the random method,with 40 patients in the control group and 40 patients in the treatment group.Patients in the control group were arranged to take Tamsulosin hydrochloride sustained release capsules,while those in the treatment group took Paishi decoction and Tamsulosin hydrochloride sustained release capsules with 2 weeks as a treatment period of treatment.After treatment,TCM syndrome score,calculi discharge rate,calculi discharging time,hydronephrosis degree and adverse reactions were compared,and the clinical efficacy and safety of Paishi decoction in the treatment of ureteral calculi(lower jiao dampness and heat type)were preliminarily evaluated.Results:1.Basic data comparison: Before treatment,the basic data(gender,age,Calculi size,TCM syndrome score,hydronephrosis degree)of the two groups were statistically processed,P>0.05,showing no statistical difference and indicating that the basic data of the two groups were comparable.2.Comparison of TCM syndrome score and total effective rate:(1)Comparison between groups:(1)Before treatment: the TCM syndrome scores of the treatment group and the control group were statistically analyzed,P>0.05,the difference was not statistically significant and was comparable.(2)After treatment: the TCM syndrome scores of the treatment group and the control group were statistically analyzed,P<0.05,the difference was statistically significant,indicating that the improvement of TCM syndrome scores in the treatment group was more obvious than the control group.(2)Comparison within groups: P<0.05,indicating that the TCM syndrome scores of the treatment group and the control group were significantly lower than those before treatment,and the TCM syndrome scores of the two groups were significantly improved.(3)Comparison of therapeutic effects: the total effective rate of the treatment group was 94.87%,and the total effective rate of the control group was 87.18%.According to the above results,TCM syndrome scores of both groups decreased after treatment,but the decrease of TCM syndrome scores of the treatment group was more obvious.3.Comparison of hydronephrosis degree:(1)Comparison between groups:(1)Before treatment: the hydronephrosis scores of the treatment group and the control group were statistically analyzed,P>0.05,the difference was not statistically significant and was comparable.(2)After treatment: the hydronephrosis scores of the treatment group and the control group were statistically analyzed,P>0.05,the difference was not statistically significant.(2)Comparison within groups: P<0.05,indicating that the hydronephrosis scores in the treatment group and the control group were significantly lower after treatment than before treatment.According to the above results,the degree of hydronephrosis in the two groups after treatment decreased significantly compared with that before treatment,but the comparison between the two groups showed no statistical significance in the score difference of hydronephrosis after treatment.4.Comparison of calculi discharge rate and calculi discharging time after treatment: the calculi discharge rate of the treatment group was 74.36%,and the calculi discharging time was 6.38±2.61 days.The calculi discharge rate of the control group was 48.71%,and the calculi discharging time was 8.74±3.33 days,the calculi discharge rate and the calculi discharging time of the two groups after treatment were analyzed,P<0.05,and the differences were statistically significant.According to the above results,the calculi discharge rate of the treatment group was higher than that of the control group,and calculi discharging time was significantly shorter than that of the control group.5.Comparison of clinical efficacy: the total effective rate of the treatment group was 89.74%,and the total effective rate of the control group was79.49%.The clinical efficacy of the two groups was statistically analyzed,P<0.05,and the differences were statistically significant.According to the above results,the clinical efficacy of the treatment group was higher than that of the control group.6.Comparison of adverse reactions after administration: In the treatment group,4 patients had mild adverse reactions,and the incidence of adverse reactions after administration was 10.26%.There were 6 patients in the control group with mild adverse reactions,and the incidence of adverse reactions after administration was 15.38%.The incidence of adverse reactions after administration in the two groups was statistically analyzed,P>0.05,the difference was not statistically significant.Conclusions:1.The combination of Paishi decoction and Tamsulosin hydrochloride sustained release capsules can significantly improve the calculi discharge rate,calculi discharging time,improve TCM syndrome score and clinical symptoms,which is more advantageous than Tamsulosin hydrochloride sustained release capsules alone.2.The combination of Paishi decoction and Tamsulosin hydrochloride sustained release capsules in the treatment of ureteral calculi(lower jiao dampness and heat type)showed no obvious side effects during the clinical observation period,with good safety,which is worthy of further clinical experimental exploration and has corresponding promotion value.