| Objective: To study the clinical effectiveness of Zhideke granules in the adjuvant treatment of community-acquired pneumonia(CAP)patients with wind-heat invading lungs by observing and comparing the improvement of Zhideke granules in combination with Western medicine and Western medicine alone on the patients’ syndrome,serum inflammatory factors,and chest CT,and to lay a foundation for its clinical use and promotion.Methods: 60 patients who sought treatment in the Department of Respiratory and Critical Care Medicine of our hospital were selected in strict accordance with the inclusion and exclusion criteria and they were then randomly and equally divided into two groups,namely,the observation group and the control group.Anti-infection and antisputum treatment was given to the control group according to the medical history,symptoms,signs,imaging,and laboratory examination results of the patients at admission.The same western medicine treatment as the control group and the traditional Chinese medicine(TCM)combined with the internal administration of Zhideke granules were given to the observation group.Both groups received a treatment course of 1week.The general data such as gender and age before the treatment,and the observation indexes such as TCM syndrome scores,interleukin-6(IL-6),serum amyloid A(SAA),neutrophil to lymphocyte ratio(NLR),C-reactive protein(CRP),chest CT,and safety indexes before and after the treatment were recorded.The efficacy difference between the two groups was comprehensively evaluated after the statistical treatment.Results:1.No significant differences were found in the general data,inflammatory indicators,syndrome scores,chest CT,and safety indicators between the two groups before the treatment(p>0.05).2.Scores of TCM single syndrome: compared with those before the treatment,scores of fever,cough,phlegm,dry mouth,and dry pharynx in both groups dropped after the treatment(p<0.05);the observation group presented a more obvious decline than the control group and statistically significant differences were identified(p<0.05).3.Total scores of TCM syndromes: compared with those before the treatment,total scores of TCM syndromes in both groups decreased after the treatment(p<0.05);the observation group presented a more obvious decline than the control group and statistically significant differences were identified(p<0.05).4.Clinical efficacy: according to the criteria of TCM syndrome efficacy,the total effective rates of the observation group and the control group were93.0% and 73.0%,respectively.The total effective rate of the former was significantly higher than that of the latter and statistically significant differences were identified(p<0.05).5.Inflammatory indicators: the levels of serum SAA,IL-6,NLR,and CRP in the two groups were significantly different from those before the treatment(p<0.05),and the inflammatory indicators in the observation group reduced more obviously than those in the control group,with statistical significance(p<0.05).6.Imaging: On the 7th day of treatment,chest CT showed that the absorption of lung inflammation in the treatment group was better than that in the control group,the difference was statistically significant(p < 0.05).7.Safety: no adverse reaction was observed between the two groups in the course of treatment,and the safety indicators such as liver and kidney function before and after the treatment showed no significant differences(p>0.05).Conclusions:1.The adjuvant treatment of Zhideke granules can effectively relieve clinical symptoms and improve the overall therapeutic effect of CAP patients(with wind-heat invading lung).2.The adjuvant treatment of Zhideke granules can effectively weaken the level of inflammatory factors and enhance lung inflammation of CAP patients(with wind-heat invading lung).3.Zhideke granules produce no adverse reactions and liver and kidney damage during the whole test,indicating that they have certain safety. |
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