Correlation Analysis Of Thyroid Hormone And Ferritin Levels With Pregnancy Outcome In Pregnant Women With Gestational Diabetes Mellitus

Objective:This study retrospectively analyzed and compared the differences of thyroid hormone levels,FT3/FT4 ratio,serum ferritin(SF)level,hemoglobin and other related factors between pregnant women with Gestational diabetes mellitus(GDM)and normal pregnant women.The correlation between thyroid hormone level,FT3/FT4 ratio,ferritin level and adverse pregnancy outcomes in GDM pregnant women was analyzed.The adverse pregnancy outcomes of GDM can be evaluated by detecting thyroid hormone and ferritin,and timely prevention,intervention and treatment can reduce the harm of GDM to mothers and infants.Methods:Firstly,100 pregnant women with GDM who had regular prenatal examination and hospitalized for delivery in the Qingdao Municipal Hospital clinic from June 2021 to December 2022 were selected as the observation group,and 100 normal pregnant women during the same period were selected as the control group.Secondly,the general data(age,gestational weeks,gravidity,parity,height,weight,pregnancy outcome)of the observation group and the control group of pregnant women were collected and recorded,and the related laboratory indicators of prenatal examination were examined: Thyroid function(free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)),FT3/FT4 ratio,hemoglobin(Hb),platelet(PLT),albumin(Alb),total cholesterol(TC),triglyceride(TG),ferritin.Excel 2019 was used to establish data files,and SPSS26.0 system software was used for statistical analysis of all data.The differences of thyroid hormone level,FT3/FT4 ratio,ferritin level,hemoglobin and other related factors between GDM women and normal women were analyzed.The correlation between thyroid hormone level,FT3/FT4 ratio,ferritin level and adverse pregnancy outcomes of GDM women in the observation group was analyzed.Results:(1)By t test,there was no significant difference in gestational age,gravidity,parity,age,hemoglobin,platelet,total cholesterol and thyroid stimulating hormone between the observation group and the control group(P > 0.05)(2)By t test,the pre-pregnancy Body mass index(BMI),triglyceride,FT4,FT3/FT4 ratio and ferritin of the observation group were higher than those of the control group,and FT3 was lower than that of the control group,and the differences were statistically significant(P < 0.05).(3)By chi-square test,the adverse pregnancy rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P < 0.05).(4)Binary Logistics regression analysis: taking the occurrence of adverse pregnancy outcomes of GDM as the dependent variable,univariate Logistic regression analysis showed that the pre-pregnancy BMI,FT3/FT4 ratio and ferritin of pregnant women in the observation group were the risk factors for adverse pregnancy outcomes of GDM,and the difference was statistically significant(P <0.05).Multivariate Logistic regression analysis showed that FT3/FT4 ratio and ferritin were independent risk factors for adverse pregnancy outcomes of GDM in the observation group after adjusting for pre-pregnancy BMI as a confounding factor,and the difference was statistically significant(P < 0.05).(5)ROC curve analysis: The ROC curve analysis of FT3/FT4 ratio and ferritin showed that FT3/FT4 ratio and ferritin both had a certain value for GDM adverse pregnancy outcome(AUC > 0.5,P < 0.05),and the combined prediction improved the predictive value for GDM adverse pregnancy outcome(AUC=0.721,specificity was 71%,Sensitivity was 72.2%).Conclusions:(1)FT3/FT4 ratio,ferritin and BMI were associated with adverse pregnancy outcomes in GDM pregnant women.(2)FT3/FT4 ratio and ferritin were independent factors affecting adverse pregnancy outcomes in GDM pregnant women,and combined with independent risk factors improved the predictive value.(3)Increased FT3/FT4 ratio and ferritin levels increased the risk of adverse pregnancy outcomes in women with GDM.