| Objective:This study was conducted by collecting early endometrial carcinoma(EC;endometrial carcinoma)and atypical hyperplasia(AH;atypical hyperplasia)ia related clinical data of patients were analyzed,including clinical features,therapeutic methods,effects and pregnancy.And then discuss its curative effect and the related influencing factors of pregnancy.Methods:A total of 61 patients with AH and early EC admitted to our hospital from June 2019 to December 2021 and receiving nursing treatment were included in the study.According to pathological diagnosis at the time of diagnosis,they were divided into the early EC group(n=14)and the AH group(n=47).Clinical characteristics,treatment methods,effects and pregnancy of the two groups were followed up and compared.Three courses of treatment were taken as the time node,and patients were divided into CR group(n=33)and no CR group(n=28)according to the outcome of nursing treatment.The therapeutic effects and influencing factors of the enrolled patients were compared.According to whether they were pregnant or not,34 patients with urgent fertility requirements were divided into pregnant group(n=11)and non-pregnant group(n=23),and their pregnancy conditions and influencing factors were compared.SPSS25.0software was used for statistical analysis,and the statistical data were analyzed by chi-square test and Fisher’s exact test.The measurement data were analyzed by T test of two independent samples.At the same time,Logistic multivariate regression was used to analyze the related factors affecting pregnancy.P<0.05 was considered to be statistically significant.Results:1.The percentage of hysteroscopic lesion resection in EC group was significantly higher than that in AH group(P=0.026).There were no significant differences in age,BMI,intima thickness at diagnosis,previous reproductive history,infertility and complications,nursing treatment,treatment outcome and fertility between the AH group and the early EC group(P>0.05).2.The mean duration of pathological complete response(CR)in AH group was 3.02±1.669 courses.The mean time of CR in EC group was 3.31±1.473 treatment courses.The time to acquire CR was significantly different between the two groups(P<0.05),that is,the time to acquire CR in the EC group was significantly longer than that in the AH group.Among 61 patients who met inclusion criteria,conservative treatment resulted in 90.1%(55/61)CR,8.2%(5/61)partial response(PR),and 1.6%(1/61)stable disease(SD).There were 47 cases in the AH group,89.4%(42/47)CR and 10.6%(5/47)PR,and the total response rate was 100%.There were 14 cases in EC group,92.9%(13/14)CR,and the total response rate was 92.9%.There was no significant difference in the overall response rate between the two groups(P>0.05).3.Age,BMI,previous reproductive history,whether combined with PCOS,and whether combined with hysteroscopic lesion resection were all factors influencing the therapeutic effect(P<0.05).There were no significant differences in intima thickness,infertility or progesterone treatment between 2 groups at diagnosis(P>0.05).Further analysis showed that the remission rate of patients younger than 35 years old was significantly higher than that of patients older than 35 years old.The remission rate of patients with BMI less than or equal to28kg/m2 was significantly higher than that of patients with BMI greater than28kg/m2.The remission rate of patients with reproductive history was significantly higher than that of patients without reproductive history.The remission rate for each course of treatment in patients with PCOS was significantly lower than those without PCOS,and the remission rate for each course of treatment in patients with combined hysteroscopic focal resection was significantly higher than those without hysteroscopic focal resection.4.Oral efficient progesterone combined LNG-IUS and Gn RH-a treatment process of adverse reactions in patients than significantly lower than patients with oral efficient progesterone,only has significant statistical difference(P < 0.05).5.The total disease recurrence rate in the early EC group and the AH group was 14.5%(8/55),7.1%(3/42)in the AH group and 38.4%(5/13)in the early EC group,the difference between the two groups was statistically significant(P<0.05).6.There were 34 patients with CR and urgent fertility requirements,and the overall pregnancy rate was 32.3%(11/34).AH pregnancy rate 26.9%(7/26),28.6%(2/7)received IVF-ET assisted reproductive technology,71.4%(5/7)received ovulation induction treatment;The pregnancy rate in the EC group was50.0%(4/8),75%(3/4)received IVF-ET assisted reproductive technology,and25.0%(1/4)received ovulation induction therapy.IVF-ET assisted reproductive technology can significantly improve the pregnancy rate of patients with CR.There were no significant differences in age,BMI,treatment time,endometrial pathological type and conception mode between pregnant and non-pregnant groups(P>0.05).Conclusion:1.Patients with early endometrial cancer and atypical endometrial hyperplasia have a higher CR rate after nursing treatment.2.Age,BMI,previous reproductive history,whether or not PCOS was involved and whether or not hysteroscopic lesion resection was performed were all factors influencing the efficacy of nursing therapy.Age over 35,BMI over28kg/m,no reproductive history,no PCOS,hysteroscopic lesion resection combined with progesterone therapy significantly increased the CR rate of nursing therapy.3.The overall recurrence rate of CR patients after nursing treatment is higher,and the recurrence rate of early EC patients is significantly higher than that of AH patients.4.It is suggested that patients with CR treated conservatively should actively cooperate with the medical advice of doctors in the reproductive center to complete the birth plan,and receiving IVF-ET assisted reproductive technology can significantly improve the pregnancy rate of patients with CR. 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