The Effect Of Huoxue Jiangni Tongfu Method On The Syndrome Of Stagnation Of Qi And Blood Stasis Of Intestinal Obstruction And The Effect Of IL-6

Objective:To observe the clinical efficacy of Huoxue Jiangni Tongfu method in the treatment of intestinal qi stagnation and blood stasis syndrome and its effect on IL-6 index,and to provide some guidance for the treatment of adhesive intestinal obstruction(AIO).Methods:Patients who were admitted to the Department of General Surgery of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from December 2021 to December 2022 were collected,and 60 eligible inpatients were selected in strict accordance with the criteria.Randomly divided into treatment group and control group 30 cases.Both groups were given routine treatment,including fasting,gastrointestinal decompression,acid suppression and gastric protection,correction of water and electrolyte balance disorders,anti-infection,rehydration and nutritional support.The control group was treated with warm saline enema on the basis of routine treatment,while the treatment group was treated with Huoxue Jiangni Tongfu enema.The general data,gastrointestinal function recovery index,abdominal pain and bloating score,efficacy evaluation and adverse reactions,as well as IL-6 and CRP levels were compared between the two groups.Results:(1)Comparison of general data : There was no significant difference in the course of disease and surgical site between the two groups(P<0.05).(2)Comparison of curative effect:In the control group,5 cases were cured,4 cases were markedly effective,13 cases were effective,8 cases were ineffective,and the total effective rate was 73.33%.In the treatment group,8 cases were cured,11 cases were markedly effective,7 cases were effective,4 cases were ineffective,and the total effective rate was 86.67 %.(3)Comparison of clinical manifestations : the recovery time of gastrointestinal function in the treatment group was earlier than that in the control group(P<0.05);after treatment,the symptom scores of the two groups were lower than those before treatment,and the treatment group was significantly lower than the control group(P<0.05).(4)Comparison of laboratory indexes : The levels of IL-6 and CRP in the two groups were lower than those before treatment,and the indexes in the treatment group decreased significantly(P<0.05).(5)Adverse reactions : There were no adverse reactions such as drug allergy during the treatment of clinical research.Only 1 young patient in the treatment group was analyzed and considered to have a transient anal discomfort after enema due to age factors.The symptoms were relieved after psychological counseling and rest for several minutes,and there was no obvious abnormality after follow-up observation.Conclusion:The results of comprehensive analysis of clinical researchshow that the advantages of traditional Chinese medicine in the treatmentof AIO are obvious.The clinical efficacy of Huoxue Jiangni Tongfu methodin the treatment of intestinal qi stagnation and blood stasis syndrome issatisfactory,which can promote the decrease of inflammatory indexes and relieve the clinical symptoms such as abdominal pain and abdominal distension.Therefore,it is of far-reaching significance to further optimize the diagnosis and treatment plan of integrated traditional Chinese and Western medicine for this disease.