Clinical Study On Jiawei Sijin Paishi Granule In Treating Chronic Calculous Cholecystitis With Damp-heat Of Liver And Gallbladder

Objective:To compare the clinical effects of Jiawei Sijin Paishi Granule and ursodeoxycholic acid in treating chronic calculous cholecystitis with damp-heat type of liver and gallbladder,analyze the theoretical basis of Jiawei Sijin Paishi Granule in treating this disease,and provide a safe and effective basis for Jiawei Sijin Paishi Granule in treating chronic calculous cholecystitis.Methods:From December 2020 to May 2021,60 patients with chronic calculous cholecystitis of damp-heat syndrome of liver and bile were randomly divided by lot method.30 patients in the treatment group were treated with Jiawei Sijinpaishi granules,one dose per day for 4 weeks,for 2 consecutive courses of treatment.Control group 30 patients were given oral medicine as ursodeoxycholic acid tablets,the specific dosage of each time is 750mg,once a night,4 weeks as a course of treatment,continuous 2 courses of treatment.TCM bed clinical syndrome score,gallbladder color ultrasound score,gallbladder stone size change score before and after treatment were recorded in the two groups,to clarify the clinical effect of Jiawei Sijinpaishi granules in the treatment of chronic calculous cholecystitis..Results:1.TCM syndrome score:After receiving treatment,all TCM syndromes in the treatment group were improved to varying degrees;Some TCM syndromes of the control group were improved.Compared with before treatment,the total scores of TCM syndromes in the two groups after treatment were reduced to varying degrees(P<0.01),but there was no statistical significance in the total scores of TCM syndromes in the two groups after treatment(P>0.05).After treatment,the main symptoms of traditional Chinese medicine(right flank pain or distension pain),secondary symptoms(body weight drowsiness,epigastric distension,short yellow urine,stool discomfort or esoterica),physical signs(gallbladder tenderness or percussion pain)scores in the treatment group were significantly reduced compared with before treatment(P<0.01),the difference was statistically significant;After treatment,the scores of TCM main symptoms(right flank pain or swelling pain,bitter mouth in the morning,dry mouth desire to drink),secondary symptoms(bad stool or secret),physical signs(gallbladder tenderness or tap pain)in the control group were significantly reduced compared with before treatment(P<0.01),and the scores of TCM syndrome secondary symptoms in the other control group were not statistically significant compared with before treatment(P>0.05).After treatment,the main symptoms of traditional Chinese medicine(right flank pain or distension pain),traditional Chinese medicine(body weight sleepiness)scores of the treatment group were significantly reduced compared with the control group,the difference was statistically significant(P<0.05),after treatment,the treatment group of secondary symptoms(abdominal distension,discomfort or constipation)was significantly lower than the control group,the difference was statistically significant(P<0.01).2.Comparison of gallbladder color ultrasound scores:After treatment,gallbladder color ultrasound scores of the two groups were significantly reduced compared with those before treatment,the difference was statistically significant(P<0.01),but after treatment,there was no statistically significant difference between the two groups of gallbladder color ultrasound scores(P>0.05).3.Comparison of calculus size change scores:After treatment,calculus size scores of the two groups were significantly lower than before treatment(P<0.01),but there was no statistical significance in calculus size scores of the two groups after treatment(P>0.05).4.Comparison of total clinical efficacy:The total clinical effective rate of the treatment group was 93.33%,the total clinical effective rate of the control group was 70.00%,the treatment group had a higher total clinical efficacy(P<0.05)Conclusion:Modified Sijinpaishi Granules have obvious curative effect in the treatment of patients with chronic calculous cholecystitis and liver dampness heat type,and can effectively improve the clinical symptoms,gallbladder color ultrasound and stone size of patients.Its total effective rate is obviously better than that of ursodeoxycholic acid tablets alone,and it has high safety...