A Clinical Study On The Treatment Of Depression In The State Of Irritability And Anxiety And Syndrome Between Heart-Kidney Disharmony By Combining Traffic Cardiorenal Remove Irritability Prescription With Escitalopram

Objective: To observe and compare the clinical efficacy of traffic cardiorenal remove irritability prescription combined with escitalopram in the treatment of depression in the state of irritability and anxiety and syndrome between heart-kidney disharmony,comprehensively evaluate its effectiveness and safety,and explore the clinical value of combining viscera with psychology in the treatment of depression.In order to provide new ideas and methods for the clinical treatment of depression with integrated traditional Chinese and Western medicine.Method: 68 cases of depression patients in the state of irritability and anxiety and syndrome between heart-kidney disharmony were included in this project,and they were divided into the treatment group and the control group according to the randomization method of numerical random table,with 34 patients in each group.The control group was given western medicine escitalopram,and the treatment group was given the Chinese medicine traffic cardiorenal remove irritability prescription on the basis of the control group.The treatment period of both groups was 8weeks.Before and after treatment,the patients in the two groups were evaluated by Hamilton Depression Scale(HAMD-17),the Chinese Medicine heart-kidney disharmony syndrome Scale,the Chinese Medicine dysphoria and anxiety state rating Scale,was conducted to observe the clinical efficacy of traffic cardiorenal remove irritability prescription combined with escitalopram in the treatment of depression.And the adverse reactions during the treatment were recorded,to assess drug safety.Results: During the trial,8 cases were dropped due to poor compliance or dropped out.After 8 weeks of treatment,there were 27 patients in the final treatment group and 33 patients in the control group.(1)Comparison of general information between the two groupsThere was no statistical difference in gender,age,and course of disease between the control group and the treatment group(P>0.05),which was comparable.(2)Comparison of HAMD-17 scores between the two groupsBefore treatment,there were no significant differences in HAMD-17 scores between the two groups(P>0.05),which was comparable.After treatment,the scores of two groups were lower than before(P<0.01).The effective rate of the control group was 72.73%,while that of the treatment group was 92.59%,so the curative effect of the treatment group was higher than that of the control group(P<0.05).(3)Comparison of the Chinese Medicine heart-kidney disharmony syndrome Scale scores between the two groups.Before treatment: there were no significant differences in the Chinese Medicine heart-kidney disharmony syndrome Scale scores between the two groups(P>0.05),which was comparable.After treatment: the scores of two groups were lower than before(P<0.01).The effective rate of heart and kidney disharmony syndrome was66.67% in the control group and 88.89% in the treatment group,which was higher than that in the control group(P<0.05).In terms of the Chinese Medicine heart-kidney disharmony high frequency syndrome scores,the treatment group was significantly better than the control group in terms of depression,loss of interest,irritability,fatigue,insomnia,decreased appetite and anxiety.(P<0.05),while there was no significant difference in dreamy between the two groups(P>0.05).(4)Comparison of the Chinese Medicine dysphoria and anxiety state rating Scale scores between the two groups.Before treatment: there were no significant differences in the Chinese Medicine dysphoria and anxiety state rating Scale scores between the two groups(P>0.05),which was comparable.After treatment,the scores of two groups were lower than before(P<0.01).The effective rate of the Chinese medicine irritability and anxiety score in the control group was 75.76%,while that in the treatment group was 96.30%,so the efficacy of the treatment group was higher than that in the control group(P<0.05).In terms of the dysphoria and anxiety state subscale scores,the treatment group was significantly better than the control group in terms of psychological discomfort,physiological discomfort and physical discomfort,(P<0.05),while there was no significant difference in head and face discomfort between the two groups(P>0.05).Conclusion: 1.The efficacy of traffic cardiorenal remove irritability prescription combined with escitalopram is better than that of escitalopram alone,with fewer adverse reactions and higher safety.2.In terms of the relieving symptoms of depression,relieving the Chinese Medicine heart-kidney disharmony syndrome(such as depression,loss of interest,irritability,fatigue,insomnia,decreased appetite and anxiety)and improving dysphoria and anxiety state(such as psychological discomfort,physiological discomfort and physical discomfort),the efficacy of traffic cardiorenal remove irritability prescription combined with escitalopram have significant advantages.