Clinical Observation Of Modified Sijunzi Decoction On Patients With Anemia(Deficiency Of Qi And Blood) After TKA

Objective: Based on the theory of "spleen regulating blood,Qi absorbing blood",Sijunzi decoction was used to prevent and treat anemia after TKA surgery of knee osteoarthritis,and to explore the TCM prevention and treatment methods of anemia(deficiency of Qi and blood)after TKA surgery.Methods: From December 2021 to December 2022,62 patients who met the inclusion criteria and were diagnosed as Knee osteoarthritis(KOA)and required total knee replacement were selected from Affiliated Hospital of Shandong University of Traditional Chinese Medicine.Randomized number table method was used to divide the patients into control group(31 cases)and treatment group(31 cases).All the surgeries were performed by the same chief physician with rich experience in joint replacement.The control group received conventional treatment,and the treatment group received modified Sijunzi decoction on the basis of conventional treatment.Tranexamic acid injection was given intravenously in both groups before operation.Preoperative basic information(gender,age,affected limb,height,weight)and laboratory indicators(fasting blood HGB,HCT)of patients were counted,intraoperative blood loss and postoperative drainage volume were recorded,abdominal blood was evacuated from the morning 1,3,5 days after surgery for HGB and HCT,total blood loss and recessive blood loss were calculated by formula,and blood transfusion volume of patients was recorded.TCM syndrome scores before and after treatment were recorded,and visual analogue scale(visual analogue scale,5 days and 45 days after surgery)was recorded.VAS)and the Hospital for special surgery knee score HSS;Lower extremity venous color doppler ultrasonography was performed 5 days after surgery to assess thrombus,and fasting blood biochemical energy was performed 5 days after surgery to assess liver and kidney function.By observing the effect of modified Sijunzi Decoction on anemia after TKA surgery,the effectiveness and safety of modified Sijunzi Decoction on anemia after TKA surgery were discussed.Results: In this study,1 patient in the treatment group and 1 patient in the control group fell off,and a total of 60 cases were completed.1.Comparison of general data: there was no statistical significance in gender,age,weight,height,affected limb and total blood volume between the two groups(P>0.05),indicating that the two groups were comparable.2.Comparison of blood loss: There was no statistical significance in the dominant blood loss between the two groups(P > 0.05),while the recessive blood loss and total blood loss in the treatment group were lower than those in the control group(P < 0.05).3.HGB and HCT: HGB and HCT values of the two groups before surgery,1 day after surgery and 3 days after surgery showed no statistical significance(P > 0.05).HGB and HCT values of the treatment group were higher than those of the control group 5 days after surgery,showing statistical significance(P < 0.05).4.HSS score: There was no statistical significance in preoperative HSS score between the two groups(P > 0.05),but HSS score 5 and 45 days after surgery in the treatment group was higher than that in the control group,with statistical significance(P < 0.05).5.VAS score: The preoperative VAS score of the two groups showed no statistical significance(P > 0.05),while the VAS score of the treatment group at 5 and 45 days after surgery was lower than that of the control group,with statistical significance(P < 0.05).6.Syndrome scores of deficiency of Qi and blood: The comparison of syndrome scores between the two groups before treatment showed no statistical significance(P > 0.05),while the syndrome scores of the treatment group were lower than those of the control group 5 and45 days after surgery,with statistical significance(P < 0.05).Conclusions: 1.Adding Sijunzi Decoction can reduce the syndrome score of Qi and blood deficiency and improve the symptoms of Qi and blood deficiency in anemia patients after TKA surgery.2.Added Sijunzi Decoction can effectively improve the HSS score of anemia patients after TKA surgery,and play an important role in improving knee joint function.3.Sijunzi Decoction can effectively improve the HGB and HCT levels of anemia patients after TKA surgery,improve anemia after TKA surgery,and has a good effect on reducing patients’ recessive blood loss,and accelerate the process of postoperative rehabilitation.4.Added Sijunzi Decoction can reduce VAS scores of anemia patients after TKA surgery,and has positive significance for improving knee pain in patients.