Study On The Risk Prediction Model Of Acute Cerebral Infarction Recurrence Based On The Distribution Of TCM Constitution

Objective To analyze the physical type and exposure characteristics of risk factors in recurrent patients with acute cerebral infarction,summarize the correlation between physical type and(or)risk factors and the recurrence of acute cerebral infarction,and then establish a model that can predict the recurrence risk of patients with acute cerebral infarction,so as to contribute to the ultimate goal of establishing and improving the prediction of stroke recurrence risk with traditional Chinese medicine characteristics.Methods The literature was analyzed to understand the classification and determination criteria of TCM constitution,the determination criteria of each risk factor and the diagnosis of stroke recurrence.A total of 696 patients from multiple centers who met the inclusion criteria were asked to fill in the case report form of "Study on the distribution of TCM Constitution and the construction of recurrence risk model of cerebral infarction" formulated by Shandong Clinical Medical Research Center for Cardiovascular and Cerebrovascular Diseases of Traditional Chinese Medicine.The basic information,risk factors and TCM constitution types of the enrolled patients were collected.According to the information of the previous form,the patients with acute cerebral infarction who were followed up by telephone within 3 months were divided into recurrence group(experimental group)and non-recurrence group(control group).The correlation between risk factors,TCM constitution and stroke recurrence,and then the risk factors and TCM constitution can be used to predict the risk of stroke recurrence.Results A total of 696 patients were enrolled in this clinical study,including gentleness constitution(170 cases),Qi-deficiency constitution(93 cases),yang-deficiency constitution(68 cases),yin-deficiency constitution(70 cases),phlegm-dampness constitution(101 cases),damp-heat constitution(92 cases),blood-stasis constitution(78 cases),qi-stagnation constitution(18 cases),and special constitution constitution(6 cases).There were 75 patients with recurrent cerebral infarction within 3 months of follow-up,including gentleness constitution(17 cases),qi-deficiency constitution(10 cases),yang-deficiency constitution(9 cases),yin-deficiency constitution(8 cases),phum-dampness constitution(10 cases),damp-heat constitution(10 cases),blood-stasis constitution(9 cases),qi-stagnation constitution(2 cases),and special constitution(0 case).The overall recurrence rate of cerebral infarction in this clinical study was10.7%.Based on the analysis of the correlation between stroke recurrence and risk factors,it was found that the recurrence of cerebral infarction was related to gender,smoking,hypertension and coronary atherosclerotic heart disease in patients with gentleness type(P<0.05).There was no significant correlation with age,weight,diabetes,hyperlipidemia,previous history of cerebral infarction,history of cerebral artery stenosis and other risk factors(P>0.05).In patients with qi deficiency,the recurrence of cerebral infarction was related to age and coronary heart disease(P<0.05),but not related to the other risk factors(P>0.05).In patients with Yang deficiency,the recurrence of cerebral infarction was related to diabetes(P<0.05),but not to the other risk factors mentioned above(P>0.05).In patients with Yin deficiency,the recurrence of cerebral infarction was related to smoking,diabetes,and previous history of cerebral infarction(P<0.05),but not to the other risk factors mentioned above(P>0.05).In patients with phlegm-dampness,the recurrence of cerebral infarction was related to body weight(P<0.05),but not related to other risk factors(P>0.05).In patients with damp-heat,the recurrence of cerebral infarction was related to hypertension(P<0.05),but not to the other risk factors mentioned above(P>0.05).In patients with blood stasis,the recurrence of cerebral infarction was related to gender(P<0.05),but not related to the other risk factors(P>0.05).In qi-depression patients,the recurrence of cerebral infarction was not found to be related to the above risk factors(P>0.05).Patients with idiopathic constitution could not be counted because the sample size was too small.In the prediction of the recurrence risk model of cerebral infarction,it was found that the recurrence risk was correlated with damp-heat quality,blood stasis quality,gender,hypertension,diabetes,coronary heart disease,and previous history of cerebral infarction.Conclusion 1.The risk factors for recurrence of acute cerebral infarction in patients with different constitutions are different.2.The recurrence of acute cerebral infarction is related to the damp-heat and blood-stasis constitution in traditional Chinese medicine.