| Objective: By observing the clinical efficacy of Fengchi Point "excessive eye heat" acupuncture combined with Qiju Dihuang pill in the treatment of dry eye with liver and kidney Yin deficiency,it provides a new idea and method for the treatment of dry eye with traditional Chinese medicine.Methods: Strictly screening 60 patients with dry eye with liver and kidney Yin deficiency who met the inclusion criteria and were admitted to the ophthalmology outpatient Department of the Affiliated Hospital of Shandong University of Chinese Medicine from November 2021 to December 2022.There were 30 cases in the treatment group(Fengchi point "excessive eye fever" acupuncture + Qiju Dihuang pill+ sodium hyaluronate eye drops)and 30 cases in the control group(Qiju Dihuang pill+ sodium hyaluronate eye drops),10 days as a course of treatment,a total of 3 courses of treatment.There were no significant differences in baseline,gender and age between the two groups(P>0.05).Traditional Chinese medicine syndrome score,Chinese Dry Eye Questionnaire scale score,tear film rupture time(BUT),tear production volume(SchirmerⅠ,SchⅠ),the cornea fluorescein staining(FL),security were observed before and after treatment.The ANOVA of repeated measures was used to evaluate the efficacy.Results:1.In this study,a total of 60 patients(30 in the treatment group and 30 in the control group)with liver and kidney Yin deficiency type dry eye who met the diagnostic criteria were included,and none of them were shed or removed during diagnosis,treatment and follow-up,and the patient compliance was good.2.Evaluation of curative effectTCM syndrome score was used as an effective evaluation index.Before treatment,TCM syndrome score of the treatment group(36.93±2.08)and TCM syndrome score of the control group(36.60±1.59),the Chi-square test showed no significant difference(P > 0.05).After 30 days of treatment,the total effective rate of the treatment group(93.3%)and the total effective rate of the control group(70%)were statistically different by Chi-square test(P<0.05).The total effective rate of the treatment group was better.3.Score of China Dry Eye QuestionnaireBefore treatment,Chinese Dry Eye Questionnaire scale score(13.80±1.96)in the treatment group and Chinese Dry eye Questionnaire Scale score(13.67±1.94)in the control group showed no significant difference in T-test between the two independent samples(P>0.05).After 30 days of treatment,the treatment group(4.80±1.16)and the control group(5.83±1.29)showed a statistically significant difference in T-test between the two independent samples(P<0.05),indicating that the treatment group had a better effect on reducing the score of Chinese Dry Eye Questionnaire.4.Tear film rupture time(BUT)Before treatment,the tear film rupture time was 2.92±1.21 in the treatment group and 2.77±1.10 in the control group,and there was no statistical difference in rank sum test(P>0.05).After 10 days of treatment,the treatment group(5.95±1.55)and the control group(4.92±1.75);After 20 days of treatment,the treatment group(9.00±2.21)and the control group(6.52±1.61)respectively.After 30 days of treatment,the treatment group(10.35±1.68)and the control group(7.50±1.19)had statistical differences in the BUT rank sum test at different time points among the three groups(P<0.05).The treatment group had better curative effect on the time of tear film rupture.5.Tear secretion(SchirmerⅠ,SchⅠ)Before treatment,the tear secretion of the treatment group was 3.10±0.86,and that of the control group was 3.27±0.78.There was no significant difference in rank sum test(P>0.05).After 10 days of treatment,the treatment group(6.48±1.03)and the control group(5.63±1.13)respectively.After 20 days of treatment,the treatment group(8.60±1.21)and the control group(7.00±0.99);After 30 days of treatment,the treatment group(10.78±1.57)and the control group(7.80±0.97)had statistically significant differences in the SchⅠrank sum test at different time points among the three groups(P<0.05).The treatment group had better therapeutic effect on tear secretion.6.the cornea fluorescent pigmentation(FL)There was no significant difference in corneal fluorescein staining between the two groups before treatment(P>0.05).After treatment,the corneal fluorescein staining difference between the two groups was statistically significant(P<0.05),and the treatment group had better treatment effect.The corneal fluorescein staining of the treatment group was significantly different before and after treatment(P<0.05),and the treatment group was effective for the treatment of corneal fluorescein staining.There was no significant difference in corneal fluorescein staining before and after treatment in control group(P>0.05),and the control group had no effect on the treatment of corneal fluorescein staining.7.Security1 patient in the treatment group developed mild hematoma after acupuncture,and the hematoma was eliminated 3 days later.Overall safety is good.Conclusion:Fengchi acupoint "excessive eye heat" acupuncture combined with Qiju Dihuang Pill in the treatment of liver and kidney Yin deficiency type dry eye can significantly reduce the TCM syndrome score,China dry eye questionnaire scale score,corneal fluorescein staining score,prolong the tear film rupture time,increase tear secretion,and good safety. |
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