Research On Morphological Analysis Of Corpus Callosum In Patients With Parkinson’s Disease Based On Geometric Morphometry

ObjectiveThis study collects the magnetic resonance information of Parkinson’s patients and healthy controls,finds the morphological differences between Parkinson’s patients and healthy controls on the corpus callosum,hopes to accurately analyze the structure and morphology of the corpus callosum of Parkinson’s patients through the measurement of the geometric morphology of the corpus callosum of Parkinson’s patients,provide a certain morphological basis for the clinical diagnosis and treatment of neurology,and hope to provide a reference for the statistical analysis of the corpus callosum morphology,this experiment can provide a new measurement method for the forensic identification of craniocerebral injury and corpus callosum injury.MethodsIn this paper,magnetic resonance imaging scans of 45 patients with Cognitive normal of Parkinson’s disease(PD-CN),50 patients with Parkinson’s disease with cognitive impairment(PD-CI)and 50 healthy controls were collected,and the collected magnetic resonance images were adjusted to obtain the most consistent median sagittal plane.8 marker points and 8semi-marker points mark the corpus callosum to form the peripheral contour of the corpus callosum.R is used to compare the average shape,generalized Platts curve analysis(GPA)is used to study shape differences,thin plate spline analysis(TPS)is used to analyze the average shape change differences,and principal component analysis(PCA)is used to test the reliability of the data.The Witelson subdivision method was used to further evaluate the shape differences of the corpus callosum.Results1.There were no significant differences in gender,age and years of education between PD-CN group,PD-CI group and healthy control group(P>0.05),the difference in MOCA scale score was statistically significant(P<0.05),and the difference in disease duration and H-Y grade between PD-CI group and PD-CN group was not statistically significant(P>0.05).2.G value test results: the G value of PD-CI group was 0.9988,the G value of healthy control group was 0.9985,and the G value of PD-CN group was0.9976,and the results were close to 1,which proved the reliability of the measurement point position.For PD-CI group and healthy control group,the homogeneity of variance covariance of mean shape data was analyzed by Box-M test,because the hypothesis of corpus callosum homogeneity was satisfied(P=0.260),so Hotelling T2 test was used for shape comparison,and it was proved that the morphological difference of corpus callosum between PD-CI group and healthy control group was statistically significant(P=0.010),and the PD-CI group and PD-CN group were analyzed in the same way.The Box-M test showed that the hypothesis of corpus callosum homogeneity was satisfied(P=0.340),and the Hotelling T2 test was used for shape comparison,and it was proved that the morphological difference of corpus callosum between PD-CI group and PD-CN group was statistically significant(P=0.027),and the PD-CN group and healthy control group were analyzed,and the hypothesis of corpus callosum homogeneity was satisfied by Box-M test(P=0.275),and the Hotelling T2 test was used for shape comparison It was demonstrated that there was a significant difference in the morphology of corpus callosum between the PD-CN group and the healthy control group(P=0.014).4.In the comparison between PD-CI group and healthy control group,the corpus callosum of PD-CI group was atrophied as a whole,in which the knee,snout,anterior middle,posterior middle,pressure part atrophy was obvious,PD-CI group and PD-CN group in the comparison of PD-CI group The main atrophy position of corpus callosum in PD-CI group was knee,posterior middle,compression part,PD-CN group and healthy control group,in which the main atrophy position of PD-CN group was snout,anterior middle,posterior middle.5.Principal component analysis was carried out on each marker point of PD-CI group and healthy control group,PD-CI group and PD-CN group and PD-CN group and healthy control group,and the results showed less outlier noise,proving the reliability of the average shape result,and at the same time,principal component analysis was carried out on PD-CI group and healthy control group,PD-CI group and PD-CN group and PD-CN group and healthy control group,which also proved this result.Conclusions1.Compared with healthy people,Parkinson’s patients have an overall atrophy of the corpus callosum,and the main atrophy position of the corpus callosum of cognitive impairment is the knee,snout-lateral body,anterior middle,posterior middle,compression part,and the cognitively normal callosum atrophy position is the snoutal lateral body,anterior middle,posterior middle.2.Compared with patients with Parkinson’s cognitive impairment and cognitively normal patients,the corpus callosum is smaller in shape,and the main atrophy locations are the knee,posterior middle,and compression area.Patients with cognitive impairment and normal cognition have different parts and degrees of atrophy of the corpus callosum,among which the corpus callosum knee and pressure atrophy can be used as a specific recognition brain region in patients with Parkinson’s with cognitive impairment.