Study On The Correlation Between Peripheral Blood Humoral Immunity Index And Intracranial Aneurysm Development

ObjectivePrevious studies have shown that changes in the immune environment are associated with the occurrence of cardiovascular and cerebrovascular adverse events,and can predict the prognosis of patients.However,the change of humoral immune environment may also be one of the risk factors for the occurrence,multiple and rupture of IA.Relevant studies at domestic and overseas are not clear,and there is insufficient evidence to prove that humoral immunity is involved in the course of IA.By detecting the humoral immunity indexes of IA patients within three days of admission and comparing them with non-IA population,this paper explores the correlation between humoral immunity indexes and IA and provides theoretical basis for further study on the role of humoral immunity in the pathogenesis of IA.MethodsSubjects:Patients diagnosed with IA in XX Hospital from January 2022 to December 2022 were selected;In addition,patients treated in XX Hospital from January 2018 to December 2022 who did not find IA were selected as the control group.Grouping:Patients were divided into groups based on whether they had ruptured aneurysms or not and whether they had multiple aneurysms.Group IA was further divided into unruptured IA group and ruptured IA group,and single IA group and multiple IA group.Analysis:Gender,age,smoking history,drinking history,history of hypertension,hypertension grade,history of diabetes,type of diabetes and history of hyperlipidemia were collected for all subjects.Humoral immune index data within 3 days of admission were collected.The differences in baseline information and humoral immunity levels between groups IA and non-IA,ruptured IA and non-ruptured IA,single IA and multiple IA were compared and analyzed.SPSS 25.0 software was used to process the data.Results1.Compared with the non-IA group,there was a statistically significant difference in diabetes history between the two groups(P<0.05).IgE(OR=1.007,95%CI:1.002～1.013,P=0.009)was an independent risk factor for the occurrence of IA,diabetes(OR=0.137,95%CI:0.047-0.397,P<0.001)were independent protective factors for the occurrence of IA;2.There were differences in serum C4 and IgA concentrations between the ruptured IA group and the unruptured IA group(P<0.05);3.There were no significant differences in gender,age,smoking,drinking,history of allergy,hypertension,diabetes,hyperlipidemia and BMI between the single and multiple IA groups(P>0.05).C4(OR=0.000,95%CI:0.000-0.0.122,P=0.008)was an independent protective factor for multiple IA,and TC(OR=1.545,95%CI:1.116-2.140,P=0.009)was an independent risk factor for multiple IA.ConclusionHigh IgE expression was an independent risk factor for the occurrence of IA.The elevated levels of C4 and IgA in the serum of patients with ruptured IA may be potential biomarkers for predicting the ruptured IA.Elevated TC is an independent risk factor for IA.In this study,there was no significant correlation between the expression levels of λ chain and κ chain in serum and the occurrence,development and rupture of IA,but further verification of large sample and multi-center data is needed.The results of this study suggest that some indicators of humoral immunity may be involved in the occurrence,development and breakdown of IA,and further experimental studies and cohort studies are needed to explore the exact mechanism of the relationship between IA and humoral immunity.