| BackgroundObesity has become a global public health challenge,and the problem of youth obesity is increasingly serious.The need for musculoskeletal health assessment is gaining growing prominence.PurposeTo evaluate the correlation among the changes in lumbar and paravertebral muscle fat content,as well as abdominal adipose depot after dietary intervention using mDixon-Quant sequence in young obese men.MethodsForty-two young obese male subjects were included in this study and participated in a 12-week Low-carbohydrate diets(LCD)intervention.As a measure of fat content,fat fraction(FF)was obtained by mDixon-Quant sequence on magnetic resonance imaging(MRI).Imaging,physical and laboratory indexes were obtained before and after intervention.Image indexes included vertebral bone marrow FF(BMFF),Psoas major fat fraction(PMFF),Erector spinae fat fraction(ESFF),paravertebral muscle average cross sectional area,subcutaneous adipose tissue(SAT),visceral adipose tissue(VAT),abdominal adipose tissue(AAT)and liver FF.Physical indexes included height,weight,BMI,waist circumference,hip circumference and waist to hip ratio.Laboratory indexes included fasting plasma glucose,fasting serum insulin,homeostasis model assessment of insulin resistance,TG,TC,HDLC,LDLC,sd-LDLC.BMFF from the first to the fifth lumbar were named BMFF1,BMFF2,BMFF3,BMFF4 and BMFF5.Pearson correlation coefficient and Spearman correlation coefficient were used to analyze the correlation among baseline indexes.Paired sample T test was used to investigate the changes of indexes after intervention.Results(1.1)Pearson correlation analysis yielded significant correlations between PMFF and BMFF at baseline(Rho>0.40,P<0.05),as well as positive correlations between ESFF and BMFF which were weaker than the former(Rho<0.40,P<0.05).BMFF1 had stronger correlations with PMFF-L,PMFF-R,ESFF-L and ESFF-R than other BMFF(Rho=0.55,0.56,0.34,0.38,P<0.05).(1.2)There was no statistically significant correlation between BMFF and abdominal adipose depot at baseline(P>0.05).PMFF is positively correlated with VAT and AAT,and the cirrelation with VAT is higher(left:Rho=0.534,P<0.001;right:Rho=0.633,P<0.001).There were positive correlations between bilateral ESFF and SAT,VAT,AAT(P<0.05).The correlations between bilateral ESFF and AAT were the highest(left:Rho=0.476,P=0.001;right:Rho=0.512,P<0.001).(2.1)After LCD intervention,BMFF,PMFF and ESFF all decreased.The degree of reduction were as follows:BMFF1 was 10.37(4.34,14.89)%,BMFF2 was 9.30(3.62,13.04)%,BMFF3 was 10.22(4.38,12.82)%,BMFF4 was 8.36(5.47,13.52)%,BMFF5 was 9.80(5.89,14.50)%,PMFF-L was 18.04±8.70%,PMFF-R was 18.57±10.07%,ESFF-L was 16.22±7.49%,ESFF-R was 16.76(9.60,21.74)%.However,BMFF had no significant correlation with bilateral PMFF or ESFF.(2.2)The relative changes of each BMFF was positively correlated with the relative changes of VAT and AAT(P<0.05),and the relative changes of bilateral PMFF and ESFF were positively correlated with the relative changes of SAT,VAT and AAT(P<0.05).Conclusions(1)The relationships among the vertebral body,the paravertebral muscle fat content and the abdominal adipose depot in young obese men help to further understand the fat metabolism of young obese group and provide more quantitative information for the maintenance of musculoskeletal health in metabolic disorders as well as the assessment of prognostic risks.(2)The changes of vertebral body and paravertebral muscle fat content after weight loss in young obese men contribute to a deeper understanding of musculoskeletal fatty infiltration in weight loss people and provide precise clues for multidimensional noninvasive assessment of weight loss efficacy. |
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